Association of environmental polycyclic aromatic hydrocarbons exposure with periodontitis in NHANES 2009–2014: A mixtures approach

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Jinqiu Sun, Feifei Guo, Lin Wang, Fulei Han, Jia Yang, Shengli Gao
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引用次数: 0

Abstract

Background

Polycyclic aromatic hydrocarbons (PAHs) can invade and cause harm to the human body through various pathways, but there is currently little research on the relationship between mixed-PAHs exposure and periodontitis. The purpose of this study was to examine the effects of mixed-urinary PAHs exposure on periodontitis in adults in the United States.

Methods

The cross-sectional study included 2749 subjects selected from the National Health and Nutrition Examination Survey (NHANES) 2009–2014 cycles. A professional examination of the periodontal status was conducted to distinguish between periodontitis and non-periodontitis based on the Centers for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) case definition. Laboratory testing of urine samples was performed to obtain the levels of urinary PAHs. Pearson correlation coefficients were utilized to determine the degree of correlation between urinary PAHs, while weighted binary logistic regression and Bayesian kernel machine regression (BKMR) were employed to evaluate the relationship between urinary PAHs and periodontitis.

Results

In a single-exposure model, 3-hydroxyfluorene (OH-3F), 2-hydroxyfluorene (OH-2F), 1-hydroxyphenanthrene (OH-1Ph), and 2-hydroxyphenanthrene and 3-hydroxyphenanthrene (OH-2,3Ph) were positively associated with periodontitis risk. In the mixed-exposure model, BKMR analysis demonstrated that mixed exposure to urinary PAHs was positively associated with periodontitis, with OH-2F being the most critical factor for the overall mixed effects (posterior inclusion probability [PIP] = 0.98). Univariate exposure–response function and univariate effects analysis revealed a positive correlation between urinary OH-2F levels and periodontitis.

Conclusions

The study reveals a significant positive correlation between exposure to mixed PAHs and periodontitis, with a particular emphasis on the pivotal role of OH-2F. Mitigating PAHs in the environment may serve as a preventive measure against periodontitis and alleviate its global public health burden.

NHANES 2009-2014中环境多环芳烃暴露与牙周炎的关系:混合方法。
背景:多环芳烃(Polycyclic aromatic hydrocarbons, PAHs)可通过多种途径侵入人体并对其造成危害,但目前关于混合PAHs暴露与牙周炎之间关系的研究很少。本研究的目的是检查混合尿多环芳烃暴露对美国成人牙周炎的影响。方法:横断面研究纳入2009-2014年全国健康与营养检查调查(NHANES)周期的2749名受试者。根据疾病控制和预防中心/美国牙周病学会(CDC/AAP)的病例定义,对牙周状况进行专业检查,以区分牙周炎和非牙周炎。对尿液样本进行了实验室检测,以获得尿液中多环芳烃的水平。采用Pearson相关系数确定尿中多环芳烃与牙周炎的相关程度,采用加权二元logistic回归和贝叶斯核机回归(BKMR)评估尿中多环芳烃与牙周炎的关系。结果:在单次暴露模型中,3 -羟基芴(OH-3F)、2-羟基芴(OH-2F)、1-羟基菲(OH-1Ph)、2-羟基菲和3-羟基菲(oh - 2,3ph)与牙周炎风险呈正相关。在混合暴露模型中,BKMR分析表明,混合暴露于尿液多环芳烃与牙周炎呈正相关,OH-2F是整体混合效应的最关键因素(后验包含概率[PIP] = 0.98)。单因素暴露-反应函数和单因素效应分析显示尿OH-2F水平与牙周炎呈正相关。结论:本研究揭示了混合多环芳烃暴露与牙周炎之间的显著正相关,并特别强调了OH-2F的关键作用。减少环境中的多环芳烃可作为预防牙周炎和减轻其全球公共卫生负担的措施。
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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