Antimicrobial susceptibility testing of anaerobic bacteria causing bacteremia: A 13-year (2010–2022) retrospective study in a tertiary hospital

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2023-11-19 DOI:10.1016/j.anaerobe.2023.102803

Jorge Ligero-López , Eduardo Rubio-Mora , Mario David Ruiz-Bastián , María Inmaculada Quiles-Melero , Juana Cacho-Calvo , Emilio Cendejas-Bueno

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Abstract

Infections from anaerobic microorganisms result from breached mucosal barriers, posing a significant mortality risk. A retrospective study at Hospital Universitario La Paz (Madrid) from 2010 to 2022 analyzed 491 (6.17 %) anaerobic bacteremia cases out of 7956 significant bacteremia cases among 171,833 blood culture requests. Bacteroides fragilis was the most frequently isolated species (28.3 %), followed by Clostridium perfringens (13.6 %). B. fragilis showed good susceptibility to amoxicillin/ clavulanic acid (86 %), piperacillin/tazobactam (86 %), and metronidazole (87.7 %). In general, non-fragilis Bacteroides species showed low susceptibility to penicillin (7 %), amoxicillin (17.5 %), and clindamycin (64.9 %). Of our 13 non-perfringens Clostridium isolates, four exhibited resistance to penicillin and four showed resistance to clindamycin. Lactobacillus species were highly susceptible to antibiotics tested. Prevotella spp. showed low susceptibility to penicillin (20 %), amoxicillin (20 %), and clindamycin (40 %). The study contributes valuable data for monitoring and improving anaerobic bacteremia treatment.

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某三级医院引起菌血症的厌氧菌药敏试验:一项为期13年(2010-2022)的回顾性研究。

厌氧微生物的感染是由于粘膜屏障的破坏造成的，具有显著的死亡风险。2010年至2022年在马德里拉巴斯大学医院进行的一项回顾性研究分析了171833例血液培养中7956例显著菌血症病例中的491例(6.17 %)厌氧菌血症。最常见的分离种是脆弱拟杆菌(28.3 %)，其次是产气荚膜梭菌(13.6 %)。脆弱芽孢杆菌对阿莫西林/克拉维酸酯(86 %)、哌西林/他唑巴坦(86 %)和甲硝唑(87.7 %)均有良好的敏感性。一般来说，非脆弱拟杆菌属对青霉素(7 %)、阿莫西林(17.5 %)和克林霉素(64.9 %)的敏感性较低。在13株非产气荚膜梭菌分离株中，4株对青霉素耐药，4株对克林霉素耐药。乳杆菌对抗生素高度敏感。普雷沃氏菌对青霉素(20 %)、阿莫西林(20 %)和克林霉素(40 %)敏感性低。该研究为监测和改善厌氧菌血症治疗提供了有价值的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.