Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy

Q1 Computer Science

Bioprinting Pub Date : 2023-10-31 DOI:10.1016/j.bprint.2023.e00322

Nour M. Al Sawaftah , William G. Pitt , Ghaleb A. Husseini

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引用次数: 0

Abstract

The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the disease. 3D printing can help overcome some of these limitations by enabling the design and fabrication of innovative scaffolds loaded with chemotherapeutics and growth factors, stimulating bone regeneration, and delivering targeted cancer treatment. Moreover, advancements in nanotechnology have opened up new possibilities for bone tissue engineering. Nanoparticles (NPs) possess size-dependent physicochemical properties. NPs can also be designed to respond to specific stimuli enhancing localized drug delivery. These unique properties can be harnessed by embedding NPs in 3D-printed scaffolds to develop multifunctional bone scaffolds with enhanced mechanical properties and drug delivery capabilities. This review evaluates the impact of incorporating NPs in 3D-printed scaffolds on bone cancer therapy and bone regeneration. First, various 3D printing techniques employed in the biomedical field are presented and explained. The article then highlights notable achievements by researchers in this area. Finally, the review discusses the current obstacles facing this technology and how they can be addressed to enable translation into clinics.

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在3D打印支架中加入纳米颗粒用于骨癌治疗

骨癌发病率低，导致诊断和治疗延迟;此外，手术切除骨肿瘤可引起明显的骨缺损，进一步阻碍了疾病的有效治疗。3D打印可以帮助克服这些限制，通过设计和制造装载化疗药物和生长因子的创新支架，刺激骨骼再生，并提供靶向癌症治疗。此外，纳米技术的进步为骨组织工程开辟了新的可能性。纳米粒子(NPs)具有大小依赖的物理化学性质。NPs也可以设计成对特定刺激作出反应，从而增强局部药物递送。这些独特的特性可以通过将NPs嵌入3d打印支架中来开发具有增强机械性能和药物传递能力的多功能骨支架。本文综述了在3d打印支架中加入NPs对骨癌治疗和骨再生的影响。首先，介绍和解释了生物医学领域采用的各种3D打印技术。文章接着强调了研究人员在这一领域取得的显著成就。最后，本文讨论了该技术目前面临的障碍，以及如何解决这些障碍，使其能够转化为临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioprinting Computer Science-Computer Science Applications

CiteScore

11.50

自引率

0.00%

发文量

审稿时长

68 days

期刊介绍： Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.