Associations of Total Fat and Fatty Acid Intake With the Risk of Type 2 Diabetes Mellitus Among Japanese Adults: Analysis Based on the JACC Study.

IF 3.7 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Epidemiology Pub Date : 2024-07-05 Epub Date: 2024-05-31 DOI:10.2188/jea.JE20230076

Akinori Yaegashi, Takashi Kimura, Kenji Wakai, Hiroyasu Iso, Akiko Tamakoshi

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引用次数: 0

Abstract

Background: We prospectively examined the associations of total fat and fatty acid intake with type 2 diabetes (T2D) among Japanese adults.

Methods: This study was conducted using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC). A validated food frequency questionnaire evaluated the intake of total fat and fatty acids. Diabetes was assessed using self-reported data. Multivariable logistic regression analysis was performed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of incident T2D across quintiles of total fat and fatty acid intake after adjusting for potential confounders.

Results: A total of 19,088 non-diabetic participants (age range, 40-79 years) enrolled in the JACC between 1988 and 1990 were included in this study. During the 5-year study period, 494 the participants developed T2D. The OR of T2D for the highest versus lowest quintiles was 0.58 (95% CI, 0.37-0.90) for total fat, 0.78 (95% CI, 0.51-1.20) for saturated fatty acid (SFA), 0.55 (95% CI, 0.35-0.86) for monounsaturated fatty acids (MUFA), 0.61 (95% CI, 0.39-0.96) for polyunsaturated fatty acids (PUFA), 0.64 (95% CI, 0.42-0.99) for n-3 PUFA, and 0.70 (95% CI, 0.45-1.09) for n-6 PUFA. Total fat and fatty acid (except SFA and n-6 PUFA) intake were inversely associated with T2D in men. Total fat and fatty acid intake were not associated with T2D in women.

Conclusion: Higher intakes of total fats, MUFA, PUFA, and n-3 PUFA were inversely associated with T2D among Japanese men.

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日本成年人总脂肪和脂肪酸摄入量与2型糖尿病风险之间的关系:基于JACC研究的分析

背景:我们前瞻性地研究了日本成年人总脂肪和脂肪酸摄入量与2型糖尿病(T2D)之间的关系。方法:本研究采用日本癌症风险评估合作队列研究(JACC)的数据。一份经过验证的食物频率问卷评估了总脂肪和脂肪酸的摄入量。糖尿病的评估采用自我报告的数据。在调整潜在混杂因素后，进行多变量logistic回归分析，计算总脂肪和脂肪酸摄入五分位数中T2D事件的比值比(ORs)和95%置信区间(CIs)。结果:共有19088名非糖尿病参与者(年龄范围，40-79岁)在1988年至1990年期间加入JACC纳入本研究。在5年的研究期间，494名参与者患上了T2D。总脂肪最高五分位数与最低五分位数的T2D比值为0.58 (95% CI, 0.37-0.90)，饱和脂肪酸(SFA) 0.78 (95% CI, 0.51-1.20)，单不饱和脂肪酸(MUFA) 0.55 (95% CI, 0.35-0.86)，多不饱和脂肪酸(PUFA) 0.61 (95% CI, 0.39-0.96)， n-3 PUFA 0.64 (95% CI, 0.42-0.99)， n-6 PUFA 0.70 (95% CI, 0.45-1.09)。总脂肪和脂肪酸(SFA和n-6 PUFA除外)摄入量与男性T2D呈负相关。总脂肪和脂肪酸摄入量与女性T2D无关。结论:在日本男性中，较高的总脂肪、MUFA、PUFA和n-3 PUFA摄入量与T2D呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.50

自引率

4.30%

发文量

172

审稿时长

6-12 weeks

期刊介绍： The Journal of Epidemiology is the official open access scientific journal of the Japan Epidemiological Association. The Journal publishes a broad range of original research on epidemiology as it relates to human health, and aims to promote communication among those engaged in the field of epidemiological research and those who use epidemiological findings.