Food stimuli decrease activation in regions of the prefrontal cortex related to executive function: an fNIRS study.

Abstract

Purpose: Overweight/obese individuals show impairments in executive functions such as inhibitory control. However, the neural mechanisms underlying these disturbances-and specifically, whether or not they involve altered activation of the specific prefrontal cortex regions-are not yet fully understood.

Methods: The motivational dimensional model of affect suggests that high approach-motivated positive affect (e.g., desire) may impair executive function. In the present study, we investigated individual differences in neural responses to videos of food stimuli, and examined brain activity during a cognitive task in an approach-motivated positive state using functional near-infrared spectroscopy (fNIRS). In Experiment 1, in 16 healthy young adults, we tested whether prefrontal cortex activation differed during a food video clip versus a neutral video clip. Then, after viewing each video clip, we tested for differences in executive function performance and prefrontal cortex activation during a Stroop task. Experiment 2 was the same, except that we compared 20 overweight/obese with 20 healthy young adults, and it incorporated only the food video clip.

Results and conclusions: The results of both experiments indicated that food stimuli decrease activation in regions of the prefrontal cortex related to executive function. This study also suggests that overweight/obese might consciously suppress their responses to a desired stimulus, yet here it seems that effect was less pronounced than in healthy controls.

Level of evidence: Level II, Cohort Studies.