A review on the recent applications of synthetic biopolymers in 3D printing for biomedical applications

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Shiva S, Asuwin Prabu R G, Gauri Bajaj, Amy Elsa John, Sharan Chandran, Vishnu Vijay Kumar, Seeram Ramakrishna
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Abstract

3D printing technology is an emerging method that gained extensive attention from researchers worldwide, especially in the health and medical fields. Biopolymers are an emerging class of materials offering excellent properties and flexibility for additive manufacturing. Biopolymers are widely used in biomedical applications in biosensing, immunotherapy, drug delivery, tissue engineering and regeneration, implants, and medical devices. Various biodegradable and non-biodegradable polymeric materials are considered as bio-ink for 3d printing. Here, we offer an extensive literature review on the current applications of synthetic biopolymers in the field of 3D printing. A trend in the publication of biopolymers in the last 10 years are focused on the review by analyzing more than 100 publications. Their application and classification based on biodegradability are discussed. The various studies, along with their practical applications, are elaborated in the subsequent sections for polyethylene, polypropylene, polycaprolactone, polylactide, etc. for biomedical applications. The disadvantages of various biopolymers are discussed, and future perspectives like combating biocompatibility problems using 3D printed biomaterials to build compatible prosthetics are also discussed and the potential application of using resin with the combination of biopolymers to build customized implants, personalized drug delivery systems and organ on a chip technologies are expected to open a new set of chances for the development of healthcare and regenerative medicine in the future.

Graphical Abstract

Abstract Image

综述了近年来合成生物聚合物在生物医学3D打印中的应用。
3D打印技术是一种新兴的技术,受到了世界各国研究者的广泛关注,特别是在卫生和医疗领域。生物聚合物是一种新兴的材料,为增材制造提供了优异的性能和灵活性。生物聚合物广泛应用于生物医学领域,包括生物传感、免疫治疗、药物输送、组织工程和再生、植入物和医疗设备。各种可生物降解和不可生物降解的聚合物材料被认为是3d打印的生物墨水。在这里,我们对合成生物聚合物在3D打印领域的应用进行了广泛的文献综述。通过对100多篇论文的分析,对近10年来生物聚合物的发表趋势进行了综述。讨论了它们的应用和基于生物降解性的分类。在随后的章节中,将详细阐述用于生物医学应用的聚乙烯、聚丙烯、聚己内酯、聚乳酸等的各种研究及其实际应用。讨论了各种生物聚合物的缺点,并讨论了未来的前景,如利用3D打印生物材料来解决生物相容性问题,并讨论了使用树脂与生物聚合物结合来构建定制植入物,个性化药物输送系统和器官芯片技术的潜在应用,预计将为未来的医疗保健和再生医学的发展开辟一系列新的机会。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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