Porous antimicrobial crosslinked film of hydroxypropyl methylcellulose/carboxymethyl starch incorporating gallic acid for wound dressing application

IF 8.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI:10.1016/j.ijbiomac.2023.128231

Vipawan Pitpisutkul , Jutarat Prachayawarakorn

{"title":"Porous antimicrobial crosslinked film of hydroxypropyl methylcellulose/carboxymethyl starch incorporating gallic acid for wound dressing application","authors":"Vipawan Pitpisutkul , Jutarat Prachayawarakorn","doi":"10.1016/j.ijbiomac.2023.128231","DOIUrl":null,"url":null,"abstract":"<div>Because of weak mechanical qualities and low degree of swelling of hydroxypropyl methylcellulose/carboxymethyl starch (HP/CMS) blended films for wound dressing application, this work prepared a unique antimicrobial crosslinked film utilizing succinic acid (SA) as a non-toxic crosslinker and gallic acid (GAL) as an antibacterial agent. It was observed that the infrared-shifted peak position of O<img>H stretching and bending in HP/CMS/SA/GAL films was caused by hydrogen bond formation among HP, CMS and GAL components. The antimicrobial crosslinked films considerably enhanced their mechanical properties and swelling degree. After adding SA and GAL, the films retained their porosity structure as observed by scanning electron images. Moreover, GAL-loaded HP/CMS/SA films could inhibit Staphylococcus aureus and Escherichia coli growth, showing their wound dressing potential. Crystallinity percentage, water vapor transmission rate, gel fraction, water solubility, water uptake and cytotoxicity were also investigated.</div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"256 ","pages":"Article 128231"},"PeriodicalIF":8.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biological Macromolecules","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0141813023051309","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Because of weak mechanical qualities and low degree of swelling of hydroxypropyl methylcellulose/carboxymethyl starch (HP/CMS) blended films for wound dressing application, this work prepared a unique antimicrobial crosslinked film utilizing succinic acid (SA) as a non-toxic crosslinker and gallic acid (GAL) as an antibacterial agent. It was observed that the infrared-shifted peak position of OH stretching and bending in HP/CMS/SA/GAL films was caused by hydrogen bond formation among HP, CMS and GAL components. The antimicrobial crosslinked films considerably enhanced their mechanical properties and swelling degree. After adding SA and GAL, the films retained their porosity structure as observed by scanning electron images. Moreover, GAL-loaded HP/CMS/SA films could inhibit Staphylococcus aureus and Escherichia coli growth, showing their wound dressing potential. Crystallinity percentage, water vapor transmission rate, gel fraction, water solubility, water uptake and cytotoxicity were also investigated.

Abstract Image

查看原文本刊更多论文

含没食子酸的羟丙基甲基纤维素/羧甲基淀粉多孔抗菌交联膜伤口敷料应用。

由于羟丙基甲基纤维素/羧甲基淀粉(HP/CMS)复合膜在伤口敷料中的机械性能较弱，溶胀程度低，本研究以琥珀酸(SA)为无毒交联剂，没食子酸(GAL)为抗菌剂制备了一种独特的抗菌交联膜。结果表明，HP/CMS/SA/GAL膜中OH拉伸和弯曲的红外位移峰位置是由HP、CMS和GAL组分之间形成氢键引起的。抗菌交联膜的力学性能和溶胀度均有显著提高。扫描电子图像显示，加入SA和GAL后，膜的孔隙结构保持不变。此外，gal负载的HP/CMS/SA膜可以抑制金黄色葡萄球菌和大肠杆菌的生长，显示出其伤口敷料的潜力。结晶度、水蒸气透过率、凝胶分数、水溶性、吸水率和细胞毒性也进行了研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.