A Donna, P G Betta, M F Cosimi, F Robutti, D Bellingeri, A Marchesini
{"title":"Putative mesothelial cell growth-promoting activity of a cytoplasmic protein expressed by the mesothelial cell. A preliminary report.","authors":"A Donna, P G Betta, M F Cosimi, F Robutti, D Bellingeri, A Marchesini","doi":"10.1159/000163525","DOIUrl":null,"url":null,"abstract":"<p><p>Mesothelioma cells produce a cytoplasmic protein unique to primary tumours of the mesothelium which induces the in vitro proliferation of human mesothelial cells in a dose-dependent fashion. When a polyclonal antibody to this protein was added to cultures of human mesothelioma cells, inhibition of their growth occurred. These results provide evidence for a growth-factor-like role of this mesothelial protein that may act through an autocrine mechanism.</p>","PeriodicalId":75839,"journal":{"name":"Experimental cell biology","volume":"57 4","pages":"193-7"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000163525","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental cell biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000163525","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Mesothelioma cells produce a cytoplasmic protein unique to primary tumours of the mesothelium which induces the in vitro proliferation of human mesothelial cells in a dose-dependent fashion. When a polyclonal antibody to this protein was added to cultures of human mesothelioma cells, inhibition of their growth occurred. These results provide evidence for a growth-factor-like role of this mesothelial protein that may act through an autocrine mechanism.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
