{"title":"Light express","authors":"Giada Forlani , Barbara Di Ventura","doi":"10.1016/j.coisb.2021.100356","DOIUrl":null,"url":null,"abstract":"<div><p>Each of us is a unique individual despite carrying almost the same genetic<span> information as anyone else. Zooming in into our body, we find the same pattern: all cells share the same genome, and yet they look and behave differently. The process of gene expression is the reason behind this fascinating phenomenon whereby the same genome is translated in different sets of molecules being present in the cell at any given time. The ability to precisely control this process endows researchers with great power, not only for basic science purposes but also for biotechnological and biomedical applications. In this review, we will discuss the current arsenal of tools that consent to control gene expression using light as the external trigger. These tools are, in most cases, preferable to those based on chemical triggers owing to the many favorable properties of light, foremost its spatial confineability and easy removal.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.coisb.2021.100356","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452310021000500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Each of us is a unique individual despite carrying almost the same genetic information as anyone else. Zooming in into our body, we find the same pattern: all cells share the same genome, and yet they look and behave differently. The process of gene expression is the reason behind this fascinating phenomenon whereby the same genome is translated in different sets of molecules being present in the cell at any given time. The ability to precisely control this process endows researchers with great power, not only for basic science purposes but also for biotechnological and biomedical applications. In this review, we will discuss the current arsenal of tools that consent to control gene expression using light as the external trigger. These tools are, in most cases, preferable to those based on chemical triggers owing to the many favorable properties of light, foremost its spatial confineability and easy removal.
期刊介绍：
Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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