Electron microscopic study of the effects of thallium poisoning on the rat cerebellum

Abstract

Rats were given thallium acetate (5 mg elemental thallium/kg body weight) intraperitoneally daily for 7 days. The brain was fixed by perfusion—fixation and small pieces of the cerebellum were processed for electron microscopy. Variegated mitochondrial profiles, increased incidence of electron — dense bodies and proliferation of Golgi zones were observed in the thallium — poisoned rat cerebellum. Multilamellar cytoplasmic bodies were discernible in the cerebellar cortex of the thallium-treated rats.