{"title":"An unusual case of hoarseness of voice related to corticosteroid treatment","authors":"R. Naseer, L.J. Buck, M. Small, M. Munavvar","doi":"10.1016/j.rmedc.2011.03.008","DOIUrl":null,"url":null,"abstract":"<div><p>Invasive aspergillus infection of the larynx is extremely rare. This report describes the case of a 56-year-old lady with Chronic Obstructive Pulmonary Disease receiving long-term inhaled corticosteroids who presented with a four-week history of progressive hoarseness, dyspnoea and cough. Sputum cultures at the time isolated <em>Aspergillus fumigatus</em>. She was commenced on a trial of Itraconazole for presumed Allergic Bronchopulmonary Aspergillosis. Due to the duration and nature of her symptoms, vocal cord biopsies were taken which revealed abundant colonies of the fungus <em>A.</em> <em>fumigatus</em> infiltrating skeletal muscle. Inhaled corticosteroids were discontinued and the patient was switched to voriconazole. She continues to make a protracted recovery and is being closely monitored.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"4 4","pages":"Pages 170-171"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2011.03.008","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory medicine CME","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1755001711000339","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Invasive aspergillus infection of the larynx is extremely rare. This report describes the case of a 56-year-old lady with Chronic Obstructive Pulmonary Disease receiving long-term inhaled corticosteroids who presented with a four-week history of progressive hoarseness, dyspnoea and cough. Sputum cultures at the time isolated Aspergillus fumigatus. She was commenced on a trial of Itraconazole for presumed Allergic Bronchopulmonary Aspergillosis. Due to the duration and nature of her symptoms, vocal cord biopsies were taken which revealed abundant colonies of the fungus A.fumigatus infiltrating skeletal muscle. Inhaled corticosteroids were discontinued and the patient was switched to voriconazole. She continues to make a protracted recovery and is being closely monitored.
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