Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial

IF 1.7 Q2 Medicine
Supriya Bhalerao , Jayshree Kharche , Shubhangi Harke
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引用次数: 0

Abstract

Background

The pre-diabetic stage is important in terms of identification and timely management due to its reversible nature. Along with other factors, insulin resistance in skeletal muscle is often considered as primary defect before development of overt hyperglycemia and Diabetes Mellitus (DM). Physical exercises are beneficial in prevention of DM by improving skeletal muscle mediated glucose metabolism. Evidence suggests that Yoga interventions appear to be equal and/or superior to exercise in most outcome measures. As the Yogic postures are relatable to exercises, they are considered to improve skeletal muscle function and reverse the pre-diabetic stage.

Methods

This open-labelled, randomized clinical study is planned to evaluate effect of Yoga interventions on muscle mass, strength, endurance and flexibility which are direct/indirect indicators of fat deposition in skeletal muscles. Association between changes in muscle quality/ functionality and glycemic control will also be explored. With ethics committee permission, 120 pre-diabetic individuals of either sex between age group of 35–49 years with BMI range of 25–35 kg/m2 and family history of Type 2 Diabetes Mellitus (T2DM) will be recruited after obtaining written informed consent. They will be randomly allocated to either Yoga or exercise group by computer generated randomized method in a 1:1 ratio. One group will receive defined Yoga interventions, while other group will receive fixed program of physical exercises. Prior to initiating this 12-week study, both groups will undergo a training session for 4 weeks under supervision of a trained instructor. The outcome measures will be parameters related to muscle quality/functionality and glucose metabolism markers.

Discussion

Our study aims to explore practicality of Yoga in pre-diabetic stage on skeletal muscle related glycemic control, which is novel. Additionally, the study will generate awareness about pre-diabetes and provide people with active coping skills for reversing it.

瑜伽干预对糖尿病前期个体骨骼肌相关葡萄糖稳态的影响:随机对照试验的研究方案
糖尿病前期由于其可逆性,在识别和及时管理方面具有重要意义。与其他因素一起,骨骼肌的胰岛素抵抗通常被认为是发展为显性高血糖和糖尿病(DM)之前的原发性缺陷。体育锻炼通过改善骨骼肌介导的葡萄糖代谢,有助于预防糖尿病。有证据表明,在大多数结果测量中,瑜伽干预似乎与运动相同或优于运动。由于瑜伽姿势与运动相关,它们被认为可以改善骨骼肌功能并逆转糖尿病前期。方法本开放标签随机临床研究旨在评估瑜伽干预对骨骼肌脂肪沉积的直接/间接指标肌肉质量、力量、耐力和柔韧性的影响。还将探讨肌肉质量/功能变化与血糖控制之间的关系。经伦理委员会许可,在获得书面知情同意后,将招募年龄在35-49岁、BMI在25-35 kg/m2之间、有2型糖尿病(T2DM)家族史的120名糖尿病前期患者,不限性别。通过计算机生成的随机方法,将他们按1:1的比例随机分配到瑜伽组和运动组。一组将接受明确的瑜伽干预,而另一组将接受固定的体育锻炼计划。在开始这项为期12周的研究之前,两组都将在一位训练有素的指导员的监督下接受为期4周的培训。结果测量将是与肌肉质量/功能和葡萄糖代谢标志物相关的参数。本研究旨在探讨糖尿病前期瑜伽对骨骼肌相关血糖控制的实用性,是一项新颖的研究。此外,这项研究将提高人们对糖尿病前期的认识,并为人们提供积极的应对技能来扭转它。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in integrative medicine
Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.20
自引率
11.80%
发文量
0
审稿时长
15 weeks
期刊介绍: Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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