Immunoglobulin and T cell receptor gene rearrangements in lymphoproliferative disorders.

Experimental cell biology Pub Date : 1989-01-01 DOI:10.1159/000163523

H Daus, G Schwarze, H Pees, H Radtke, G Kümel, P G Scheurlen

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引用次数: 5

Abstract

Thirty-one samples representing Hodgkin's and non-Hodgkin's lymphomas, angioimmunoblastic lymphadenopathy (AILD), and benign follicular hyperplasia in HIV infections were examined for rearrangements of the immunoglobulin (Ig) and T cell receptor (TcR) beta-chain gene loci. In 11 of 12 non-Hodgkin's lymphomas (classified as Burkitt lymphoma (2), centrocytic lymphoma (1), centrocytic-centroblastic lymphoma (5), centroblastic lymphoma (3], only rearranged Ig genes could be detected. The exceptional case was an unclassified high-grade lymphoma, which represented a rearrangement of the TcR beta-chain. We also examined DNA from lymphoid neoplasms in which the lineage of the malignant cell was still controversial. Rearrangement of the TcR could exclusively be demonstrated in all 3 cases of AILD. One Ig gene rearrangement and 4 TcR beta-chain rearrangements were found in 13 samples of Hodgkin's lymphomas (11 lymph nodes, 1 pleura effusion and 1 bone biopsy with proven infiltration). Examination of 3 cases of benign follicular hyperplasia in HIV infection represented one Ig rearrangement.

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淋巴细胞增生性疾病中的免疫球蛋白和T细胞受体基因重排。

我们检测了31个HIV感染的霍奇金淋巴瘤和非霍奇金淋巴瘤、血管免疫母细胞淋巴结病(AILD)和良性滤泡增生的样本中免疫球蛋白(Ig)和T细胞受体(TcR) β链基因位点的重排。在12例非霍奇金淋巴瘤(分类为Burkitt淋巴瘤(2例)、嗜中心细胞淋巴瘤(1例)、嗜中心细胞-嗜中心细胞淋巴瘤(5例)、嗜中心细胞淋巴瘤(3例)中，11例仅检测到重排的Ig基因。这个例外的病例是一个未分类的高级别淋巴瘤，它代表了TcR β链的重排。我们还检查了来自淋巴样肿瘤的DNA，其中恶性细胞的谱系仍有争议。3例AILD均显示TcR重排。13例霍奇金淋巴瘤(11例淋巴结，1例胸膜积液和1例骨活检证实浸润)中发现1例Ig基因重排和4例TcR β链重排。3例HIV感染的良性卵泡增生表现为一次Ig重排。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Experimental cell biology

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