Biomaterials based growth factor delivery for brain regeneration after injury

Abstract

Brain injury often caused irreversible loss of neural tissue and resulted in serious neurological disability. Owing to the extreme complexity of the brain, it is still challenging to regenerate the brain tissue from injury and restore its normal function. Growth factors are critical signaling molecules that promote endogenous neural stem/progenitor cells (NSPCs) proliferation, migration and differentiation, resulting in functional brain recovery from injury. However, the labile nature of growth factor motivated us to develop advanced growth factor delivery strategies to precisely control over its release profile in vivo. In this review, we will discuss growth factor delivery via biomaterials for brain regeneration after injury. This review begins with an overview of some major forms of brain injury. The characteristic properties of growth factors are described to provide a biological basis for their use in the brain regeneration. The specific biomaterials that generally used for delivering growth factor to treat brain injury are also detailed summarized. In particular, we focus on an engineering strategy that promote endogenous repair by creating growth factor concentration gradients in vivo. The last part of the review introduces current challenges and perspectives for growth factor delivery via biomaterials.