[Hypothalamic inhibiting factor of luteinizing hormone secretion: relation to the fragment 1-5 of the LH releasing hormone].

M de la Lastra, J Leal
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Abstract

In this paper we review the mechanisms underlying the control of gonadotrophin (Gn) release and present evidences of the existence of a luteinizing hormone release-inhibitory factor. We have extracted and partially characterized this factor from rat hypothalamus and bovine median eminence. Our data indicate that the factor is a peptide that has a common antigenic determinant with GnRH, but is of smaller molecular weight than GnRH (750 daltons approximately). These facts strongly suggest that it may be a fragment of the GnRH molecule. The synthetic fragment GnRH (1-5) has similar biologic effects and molecular weight to those of the inhibitory factor obtained from the median eminence and hypothalamus. GnRH (1-5) has been shown to be produced in vitro by cleavage of GnRH by an hypothalamic endopeptidase. Based on this evidences, we suggest that the inhibitory peptide found by us is formed in vivo by degradation of GnRH. Moreover, we suggest that this factor may play a role on the regulation of LH release induced by GnRH.

[下丘脑促黄体生成素分泌抑制因子:与LH释放激素片段1-5的关系]。
本文综述了控制促性腺激素(Gn)释放的机制,并提出了黄体生成素释放抑制因子存在的证据。我们从大鼠下丘脑和牛正中隆起中提取并部分表征了该因子。我们的数据表明,该因子是一种肽,与GnRH具有共同的抗原决定因素,但分子量比GnRH小(约750道尔顿)。这些事实有力地表明,它可能是GnRH分子的一个片段。合成片段GnRH(1-5)与从中隆起和下丘脑获得的抑制因子具有相似的生物学效应和分子量。GnRH(1-5)已被证明是由下丘脑内肽酶在体外切割GnRH产生的。基于这些证据,我们认为我们发现的抑制肽是通过GnRH的降解在体内形成的。此外,我们认为该因子可能在GnRH诱导的LH释放调控中发挥作用。
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