Marzieh Latifi Dr. , Farzaneh Bagherpour , Habib Rahban Dr. , Elahe Pourhossein , Sanaz Dehghani Dr.
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引用次数: 0
Abstract
Introduction
During brain death, several events occur, including hormonal. metabolic and systemic changes. This systematic review aims to find the role of hormone therapy in cadaver donors and its impact on graft function and/or survival following solid organ transplantation.
Method and materials
Randomized clinical trials were reviewed to investigate the effects of hormone therapy on graft survival amongst brain death cases. studies from Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were identified and reviewed for this current work. Two reviewers independently rated the quality of the study. As a result, 18 studies met inclusion criteria and were included in this study.
Results
Over 2235 titles were retrieved from various search sources and 16 full papers were identified for possible inclusion. Trial sample sizes varied widely from 25 to 12,333 patients. Multiple therapy schemes were developed and applied for brain death donors. The first scheme simply involved applying Triiodothyronine, Dopamine, Immunosuppressive, Vasopressin and Desmopressin separately. The second scheme consisted of applying double hormone therapy using Methylprednisolone and Vasopressin simultaneously. Finally, triple hormone therapy was applied which included Methylprednisolone, Triiodothyronine and Arginine vasopressin.
Conclusions
Results from this systematic study indicated no significant effects on overall organ survival in recipients who received brain death hormone therapy. Thus, the potential effects of hormone therapy in brain death scenarios are still unknown and need further investigation.
期刊介绍:
To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI