Quantitative electron microscopy of carcinogen-induced alterations in hepatocyte rough endoplasmic reticulum. II. Modulation of the effects of 3'MeDAB by adrenalectomy and adrenal corticosteroids.

D J Winton, B Flaks
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Abstract

A quantitative electron microscope study was made of the effects of bilateral adrenalectomy (ADX) and deoxycorticosterone acetate (DOCA) on the state of aggregation of hepatocyte rough ER cisternae in both untreated and 3'MeDAB-fed Leeds strain rats. Disaggregation of hepatocellular rough ER appears to be a common response of the rat liver to hepatocarcinogenic insult, while ADX and DOCA treatment are known to inhibit the chemical induction of neoplasia in this species. In untreated animals both ADX and DOCA significantly increased the mean number of cisternae per array or stack, while an even more pronounced effect was obtained from a combination of the two. The carcinogen 3'MeDAB induced a highly significant loss of aggregation, which was prevented by the combination of ADX and DOCA. In a separate experiment, a single dose of cortisone acetate was also found to partially reverse 3'MeDAB-induced rough ER disaggregation. In the rat hepatocyte, rough ER stacking or aggregation appears to be at least partially under hormonal control.

致癌物诱导肝细胞粗内质网改变的定量电镜观察。2肾上腺切除术和肾上腺皮质激素对3'MeDAB作用的调节。
采用定量电镜观察双侧肾上腺切除术(ADX)和醋酸脱氧皮质酮(DOCA)对未治疗和3' medab喂养利兹大鼠肝细胞粗ER池聚集状态的影响。肝细胞粗ER的分解似乎是大鼠肝脏对肝癌损伤的常见反应,而已知ADX和DOCA治疗可抑制该物种肿瘤的化学诱导。在未经处理的动物中,ADX和DOCA都显著增加了每个阵列或堆栈的平均池数,而两者的组合则获得了更明显的效果。致癌物3'MeDAB诱导了高度显著的聚集性损失,而ADX和DOCA联合使用可以防止这种损失。在另一项实验中,单剂量的醋酸可的松也被发现部分逆转3' medab诱导的粗内质网分解。在大鼠肝细胞中,粗略的内质网堆积或聚集似乎至少部分受激素控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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