Physiological and behavioral effects of hormonal contraceptive treatment in captive, pair-bonded primates (Plecturocebus cupreus).

Chloe L Karaskiewicz, Melissa Ramirez, Karen L Bales
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Abstract

Hormonal contraception is an effective, reversible tool for managing birth rates in humans and nonhuman animals alike. However, manipulating reproductive hormones has behavioral consequences that can impact social and sexual behavior between conspecifics. First, we studied 18 pairs of nonreproductive titi monkeys (Plecturocebus cupreus) to test the efficacy of a novel method of hormonal contraception (deslorelin acetate implants) on reproductive hormone cycling in females and found significant reductions in urinary estrogens and progestagens among treated females compared to untreated controls. We then studied 35 nonreproductive pairs of coppery titi monkeys (Plecturocebus cupreus) to ascertain whether treating females with one of 2 different forms of hormonal contraception (deslorelin acetate implants (n = 17) or medroxyprogesterone acetate injections (n = 9)) would influence the relationship between pair mates compared to the relationship between untreated females and their vasectomized male mates (n = 9). Over a 5-month period, we found no differences in affiliative behaviors between pairs containing untreated females compared to pairs in which the female was treated with either deslorelin acetate or medroxyprogesterone acetate. Similarly, we found no differences in affiliation between pairs in the 2 treatment groups. This study is the first to examine behavioral consequences of hormonal contraception in a pair-bonding species. The results are encouraging for captive, managed breeding colonies of such social animals, especially those used in behavioral research.

激素避孕对圈养、成对结合灵长类动物(Plecturocebus cupreus)生理和行为的影响。
激素避孕是一种有效的、可逆的工具,可以控制人类和非人类动物的出生率。然而,操纵生殖激素会产生行为后果,影响同种生物之间的社会和性行为。首先,我们研究了18对无生殖能力的胸猴(Plecturocebus cupreus),以测试一种新的激素避孕方法(醋酸地氯瑞林植入物)对雌性生殖激素循环的功效,发现与未治疗的对照组相比,治疗过的雌性尿液中的雌激素和孕激素显著减少。然后,我们研究了35对不能生育的铜胸猴(Plecturocebus cupreus),以确定是否用两种不同形式的激素避孕(醋酸地氯瑞林植入物(n = 17)或醋酸甲羟孕酮注射物(n = 9))中的一种来治疗雌性,与未治疗的雌性与输精管切除的雄性伴侣(n = 9)相比,会影响配对伴侣之间的关系。我们发现,与使用醋酸地洛瑞林或醋酸甲孕酮治疗的雌鼠相比,未经治疗的雌鼠的亲和行为没有差异。同样,我们发现在两个治疗组中,配对间的隶属关系没有差异。这项研究是第一次在一对结合的物种中检查激素避孕的行为后果。这一结果对于圈养的、有管理的群居动物繁殖地来说是令人鼓舞的,尤其是那些用于行为研究的动物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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