Influence of the new dispersible fixed-dose combination anti-Tuberculosis drug on treatment adherence among children with Tuberculosis in Osun State, Nigeria.

IF 2.3 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Obioma Chijioke-Akaniro, Patrick A Akinyemi, Sunday Asuke, Chukwuma Anyaike, Ndubuisi A Uwaezuoke, Urhioke Ochuko, Emperor Ubochioma, Amos Omoniyi, Corinne S Merle, Soji Daniel
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引用次数: 0

Abstract

Background: The dispersible fixed-dose combination drug has been recommended as the mainstay of treatment for TB in children. However, more needs to be known about its effect on treatment. This study aimed to assess the effectiveness of the formulation on treatment adherence among children with TB.

Methods: A historical cohort design was used to assess and compare adherences of old loose non-dispersible and new dispersible fixed-dose anti-TB drugs, using a convergent parallel mixed-method approach for data collection. Determinants of treatment adherence were assessed using binary logistic regression.

Results: The proportion of children with good treatment adherence was higher in the new dispersible formulation group (82 [64.6%]) relative to the proportion among the loose non-dispersible formulation group (29 [23.4%]). Reports of forgetfulness, travelling and pill burden were significantly higher among those with poor adherence in the loose non-dispersible formulation group. Significant predictors of treatment adherence were acceptability (adjusted OR [AOR]=4.1, p=0.013, 95% CI 1.342 to 12.756), travelling from treatment areas (AOR=8.9, p=0.002, 95% CI 2.211 to 35.771) and forgetfulness (AOR=74.0, p<0.001, 95% CI 23.319 to 234.725).

Conclusions: The determinants of treatment adherence are multifactorial. In addition to ensuring universal access to the drug, flexible referral in case of travelling and ensuring treatment partners' participation to minimise forgetfulness to take pills, are essential.

尼日利亚Osun州新型分散固定剂量联合抗结核药物对结核病儿童治疗依从性的影响
背景:分散固定剂量联合用药已被推荐为儿童结核病的主要治疗方法。然而,它对治疗的影响还有待进一步了解。本研究旨在评估该制剂对结核病儿童治疗依从性的有效性。方法:采用历史队列设计,采用趋同平行混合方法收集数据,评估和比较旧的松散非分散和新的分散固定剂量抗结核药物的依从性。采用二元逻辑回归评估治疗依从性的决定因素。结果:新型分散制剂组治疗依从性较好的患儿比例(82例[64.6%])高于松散非分散制剂组(29例[23.4%])。在依从性差的松散非分散制剂组中,健忘、旅行和药丸负担的报告明显更高。治疗依从性的显著预测因子为可接受性(调整后的OR [AOR]=4.1, p=0.013, 95% CI 1.342 ~ 12.756)、离开治疗区域(AOR=8.9, p=0.002, 95% CI 2.211 ~ 35.771)和遗忘(AOR=74.0, p)。结论:治疗依从性的决定因素是多因素的。除了确保普遍获得药物外,在旅行时灵活转诊和确保治疗伙伴的参与以尽量减少忘记服用药物也是必不可少的。
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来源期刊
International Health
International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
4.50
自引率
0.00%
发文量
83
审稿时长
>12 weeks
期刊介绍: International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.
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