Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults.

IF 2.6 3区心理学 Q3 NEUROSCIENCES

Neuropsychology Pub Date : 2024-02-01 Epub Date: 2023-11-16 DOI:10.1037/neu0000928

Roos J Jutten, Rebecca E Amariglio, Paul Maruff, Michael J Properzi, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Kathryn V Papp

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引用次数: 0

Abstract

Objective: To investigate whether intraindividual variability (IIV) in reaction time (RT) over monthly administered cognitive tasks is increased in cognitively unimpaired older adults who are at risk for cognitive decline, and whether this is independent of mean RT performance.

Method: N = 109 cognitively unimpaired individuals (age 77.4 ± 5.0, 61.5% female, Mini-Mental State Examination 29.1 ± 1.3) from the Harvard Aging Brain Study completed the self-administered Computerized Cognitive Composite (C3) monthly at home for up to 1 year (12.7 ± 3.2 C3 assessments). Baseline C3 assessment coincided with routine in-clinic visits, including amyloid and tau positron emission tomography imaging and standardized cognitive testing, with cognitive testing repeated annually (1.6 ± 1.2 years follow-up). The C3 includes two simple RT tasks and two complex RT tasks. IIV estimates were derived by computing intraindividual standard deviations on residual RT scores after regressing out age and session order effects. Cross-sectional associations of IIV with cognition (global cognition, memory, executive functions [EF], processing speed) and amyloid and tau burden were examined using linear regression analyses correcting for demographics and mean RT. The association between IIV and cognitive decline was assessed using linear mixed models correcting for demographic factors, mean RT, and amyloid burden.

Results: After adjusting for mean RT, increased IIV on complex RT tasks was independently associated with worse EF performance (β = -0.10, 95% CI [-.16, -0.03], p = .004), greater inferior-temporal tau deposition (β = 0.18, 95% CI [0.02, 0.34], p = .024), and faster cognitive decline in those with elevated amyloid (β = -0.62, 95% CI [-1.18, -0.06], p = .033).

Conclusions: Increased variability in monthly RT may reflect subtle EF deficits and provide unique information about short-term cognitive decline in preclinical Alzheimer's disease. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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在认知能力未受损的成年人中，反应时间表现的个体差异性增加与新出现的认知能力下降有关。

目的:研究在有认知能力下降风险的认知功能未受损的老年人中，反应时间(RT)在每月进行的认知任务中的个体变异性(IIV)是否增加，以及这是否独立于平均RT表现。方法:来自哈佛老化脑研究的109名认知功能未受损的个体(年龄77.4±5.0岁，61.5%为女性，Mini-Mental State Examination 29.1±1.3)每月在家中完成自我管理的计算机认知复合(C3)测试，为期1年(12.7±3.2次C3评估)。基线C3评估与常规门诊就诊一致，包括淀粉样蛋白和tau正电子发射断层成像和标准化认知测试，每年重复认知测试(随访1.6±1.2年)。C3包括两个简单的RT任务和两个复杂的RT任务。iv估计值是通过计算残差RT评分的个体内标准差，在剔除年龄和治疗顺序的影响后得出的。IIV与认知(整体认知、记忆、执行功能[EF]、处理速度)以及淀粉样蛋白和tau蛋白负担的横断面关联采用校正人口统计学因素和平均RT的线性回归分析进行检验。IIV与认知能力下降之间的关联采用校正人口统计学因素、平均RT和淀粉样蛋白负担的线性混合模型进行评估。结果:在调整平均RT后，复杂RT任务中IIV的增加与EF表现较差独立相关(β = -0.10, 95% CI[-])。16， -0.03]， p = 0.004)，颞下tau沉积更大(β = 0.18, 95% CI [0.02, 0.34]， p = 0.024)，淀粉样蛋白升高的患者认知能力下降更快(β = -0.62, 95% CI [-1.18， -0.06]， p = 0.033)。结论:每月RT变动性的增加可能反映了微妙的EF缺陷，并提供了临床前阿尔茨海默病短期认知能力下降的独特信息。(PsycInfo数据库记录(c) 2023 APA，版权所有)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.

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