Pneumococcus downregulates the molecular weight of the extracellular domain of the epidermal growth factor receptor of alveolar epithelial cells

IF 1.9 4区医学 Q4 IMMUNOLOGY

Microbiology and Immunology Pub Date : 2023-11-17 DOI:10.1111/1348-0421.13103

Toshihito Isono, Satoru Hirayama, Hisanori Domon, Yutaka Terao

引用次数: 0

Abstract

Pneumococcus is themajor cause of bacterial and invasive pneumococcal infections. Disrupting the alveolarepithelial barrier is an important step in the pathogenesis of invasivepneumococcal infections. The epidermal growth factor receptor (EGFR) maintainsthe integrity of the alveolar epithelial barrier. In this study, we showed that secretory pneumococcal molecules decrease the molecular weight of EGFR without peptide degradation and inhibit alveolar epithelial cell proliferation via EGFR.

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肺炎球菌下调肺泡上皮细胞表皮生长因子受体胞外结构域的分子量。

肺炎球菌是细菌性和侵袭性肺炎球菌感染的主要原因。破坏肺泡上皮屏障是侵袭性肺炎球菌感染发病机制的重要步骤。表皮生长因子受体(EGFR)维持肺泡上皮屏障的完整性。在这项研究中，我们发现，分泌性肺炎球菌分子降低EGFR的分子量而不降解肽，并通过EGFR抑制肺泡上皮细胞的增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Immunology 医学-免疫学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.