Essential oil and its nanoemulsion of Eucalyptus cladocalyx: chemical characterization, antioxidant, anti-inflammatory and anticancer activities.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-08-01 Epub Date: 2023-11-16 DOI:10.1080/09603123.2023.2280119

Sarra Dakhlaoui, Soumaya Bourgou, Feten Zar Kalai, Majdi Hammami, Makram Essafi, Slim Jallouli, Kamel Msaada

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Abstract

Formulating a nanoemulsion (NE) of essential oil (EO) could enhance its efficiency while requiring lower concentrations. Eucalyptus cladocalyx F. Muell EO was rich in monoterpenes hydrocarbons. NE was prepared and the effect of surfactant (Tween 20, 40 and 80) and shearing time were investigated. The results showed that the best NE was formed using Tween 80 after 25 min of emulsification. Small droplet size (40 nm), low polydispersity index PDI (0.49), and stable zeta potential highlighted the excellent NE stability which was tested under storage conditions for 4 months. The results showed that the antioxidant and anticancer activities of NE were enhanced compared to free EO. Furthermore, NE and EO exhibited high anti-inflammatory effects by inhibiting nitric oxide (NO), Interleukin 6 (IL-6), and tumor necrosis factors alpha (TNF-α) production in liposaccharides (LPS)-induced RAW264.7 cells. In conclusion, a stable Eucalyptus cladocalyx-NE was produced, with improved biological activities.

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桉叶精油及其纳米乳:化学性质、抗氧化、抗炎和抗癌活性。

制备精油纳米乳可以提高精油的效率，同时降低精油的浓度。桉叶(Eucalyptus cladocalyx F. Muell EO)含有丰富的单萜化合物。制备了NE，考察了表面活性剂(Tween 20、Tween 40、Tween 80)和剪切时间对NE的影响。结果表明，乳化25 min后，用吐温80形成的NE效果最佳。微滴尺寸小(40 nm)，多分散性指数PDI低(0.49)，zeta电位稳定，在4个月的储存条件下，NE具有良好的稳定性。结果表明，与游离EO相比，NE的抗氧化和抗癌活性明显增强。此外，NE和EO通过抑制脂多糖(LPS)诱导的RAW264.7细胞中一氧化氮(NO)、白细胞介素6 (IL-6)和肿瘤坏死因子α (TNF-α)的产生，表现出较高的抗炎作用。综上所述，得到了一种稳定的叶桉，其生物活性有所提高。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.

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