Efficacy of Ethanolic Extracts for Two Plants on Wound Healing in Diabetic Albino Rats

Chettinad Health City Medical Journal Pub Date : 2023-06-30 DOI:10.24321/2278.2044.202327

Girish Kumar Vyas

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Abstract

Background: Wounds in diabetic patients are critical to treat. The use of allopathic drugs has various side effects, hence new natural sources for therapies are vital. Materials and Methods: This research aimed to determine the possibility of wound healing by the ethanolic extract of Eucalyptus globulus leaves and Curcuma longa rhizomes. Albino rats were given oral administration of various plant extracts in order to find out how plant extracts affected diabetic rats’ wound healing. Results: These plant extracts greatly accelerated the wound’s ability to heal in diabetic or non-diabetic rats (p < 0.05). This increases the proliferation and migration of the fibroblast resulting in a faster healing process. These plant extracts do not cause cytotoxicity. After treatment, less amount of cell death was found for both plant extracts. The results were found to be positive. Conclusion: This research indicates that the ethanolic extracts of both plants have the potential to be used as novel therapeutics for diabetic patients’ wound healing. How to cite this article:Vyas GK, Sharma H, Vyas B, Sharma A, Sharma M. Efficacy of Ethanolic Extracts for Two Plants on Wound Healing in Diabetic Albino Rats. Chettinad Health City Med J. 2023;12(2):46-55. DOI: https://doi.org/10.24321/2278.2044.202327

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两种植物乙醇提取物对糖尿病白化大鼠创面愈合的影响

背景:糖尿病患者的伤口是治疗的关键。对抗药物的使用有各种各样的副作用，因此新的天然来源的治疗是至关重要的。材料与方法:研究蓝桉叶和姜黄根茎乙醇提取物对伤口愈合的影响。为了研究植物提取物对糖尿病大鼠创面愈合的影响，我们给白化大鼠口服各种植物提取物。结果:这些植物提取物对糖尿病大鼠和非糖尿病大鼠的伤口愈合有显著的促进作用(p <0.05)。这增加了成纤维细胞的增殖和迁移，导致更快的愈合过程。这些植物提取物不会引起细胞毒性。处理后，两种植物提取物的细胞死亡率均较低。结果是阳性的。结论:这两种植物的乙醇提取物具有作为糖尿病创面愈合新药物的潜力。Vyas GK, Sharma H, Vyas B, Sharma A, Sharma M.两种植物乙醇提取物对糖尿病白化大鼠创面愈合的影响。中国卫生与城市医学杂志，2013;12(2):46-55。DOI: https://doi.org/10.24321/2278.2044.202327

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Chettinad Health City Medical Journal

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