The Effect of Aerobic Training and Nanomicelle Curcumin Supplementation on MDA and BAX And BCL2 Activity Levels on Cardiotoxicity of Mice Infected with Breast Cancer in the Phase of Mani with Doxorubicin

Abstract

Background: Doxorubicin is a universal drug in the treatment of all types of cancers, which is limited due to its many side effects. Therefore, the present study has investigated the effect of aerobic exercise and the use of curcumin nano micelles on the activity levels of BAX, BCL2, and MDA concentration in doxorubicin-induced cardiotoxicity in mice with breast cancer. Methods: In this research, which was of a fundamental type and controlled experimentally, 24BalbC female rats were randomly divided into 4 groups: doxorubicin, doxorubicin patient and exercise, doxorubicin patient and nano curcumin supplement and doxorubicin patient, exercise and supplement. Breast cancer induction was done with MC4-L2 cells. Doxorubicin 2mg/kg was injected subcutaneously 6 times on day 28, 21, 14, 7, 1 and 35. The aerobic program consisted of 5 sessions per week for 42 days with an increase in the speed of the treadmill every two weeks including 14, 16, and 18 meters per minute and the use of nano curcumin at a dose of 100mg/k. The collected data were analyzed with a two-way analysis of variance with a significance level of 0.05 in the tests. Results: 6 weeks of aerobic training had no effect on BCL2 activity and MDA concentration, but it significantly decreased BAX activity. Taking nano curcumin supplement for 6 weeks decreased BAX activity and MDA concentration and significantly increased BCL2 activity. Conclusion 6 A week of aerobic training along with nano curcumin supplementation did not affect BAX activity and MDA concentration, but it caused an increase in BCL2 activity (p value < 0.05). Conclusion: Aerobic exercise and the use of curcumin nano micelle supplement separately or at the same time can be effective in reducing the cardiac toxicity of doxorubicin in patients with breast cancer.