Suitability of an analytical method for metoprolol tartrate coated tablet

Abstract

The suitability of an analytical method determines the characteristic performance of a method when it evaluates parameters such as selectivity, accuracy, precision and robustness. Thus, this research aims at describing the suitability of an analytical chromatographic method to determine metoprolol tartrate content in a coated tablet. This method has been considered accurate and robust since its results were recorded according to the recommended acceptance criteria (98-102%). This method was also considered precise as the results were close to two precisions to metoprolol tartrate (on 1st and 2nd days) and achieved the acceptance criteria established for such parameter. Besides, no peak degradation product coeluted with metoprolol peak, and all samples submitted to stress showed spectral purity regarding this peak. Finally, the analytical method has been considered selective, accurate, precision and robust to analyze metoprolol tartrate content.