Distribution and antifungal susceptibility of clinical Trichosporon spp. isolates: 10 years of single-center experience

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL
Hatice Hale GÜMÜŞ
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 Materials and Methods: This was a retrospective cross-sectional descriptive study, conducted between January 1, 2013 and February 5, 2023. Cultures which Trichosporon spp. isolated (n=125) were screened, and those met the eligibility criteria were included (n=77). Identification, antifungal susceptibility test results, age, gender records were identified from Microbiology Laboratory Information Management System. 
 Results: 97.4% of the isolates were Trichosporon asahii, and 2.6% were Trichosporon mucoides. The most frequent isolation period was the 2016 and 2019 year group (71.4%), not during the COVID-19 Pandemics (19.5%). The most common sample type was urine (58.4%), of whom predominantly (58.4%) hospitalized in the Intensive Care Unit. Amphotericin B MICs were ≤1µg/ml in 68.9% of the isolates. Fluconazole and voriconazole MICs were ≤1µg/ml in 20.0% and 94.8%, respectively. 59.7% of the isolates had a MIC of ≥4µg/ml for flucytosine. Micafungin and caspofungin MICs were ≥4µg/ml in 88.3% and 92.2% of the isolates, respectively. Voriconazole had the strongest in vitro activity, and amphotericin B had lower MICs than expected. The combination therapy of voriconazole and amphotericin B could be a therapeutic option in this setting, as well as monotherapy of voriconazole.
 Conclusion: Trichosporon spp. isolated in clinical specimens and their antifungal susceptibility depend on the geographic region and the anatomic site. Identifying local data will contribute to both the management of these patients, and surveillance studies.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.3000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cukurova Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17826/cumj.1348790","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: The genus Trichosporon, which is a yeast-like basidiomycete, is ubiquitous in nature and a part of human microbiota. It’s an oppurtunistic fungal pathogen, which was once rare, but increasing dramatically recently, leading to fatal infections. The aim of this study was to determine the prevalence, and antifungal susceptibility of clinical Trichosporon spp. isolates, and to determine whether there was a change in incidence during the COVID-19 Pandemic. Materials and Methods: This was a retrospective cross-sectional descriptive study, conducted between January 1, 2013 and February 5, 2023. Cultures which Trichosporon spp. isolated (n=125) were screened, and those met the eligibility criteria were included (n=77). Identification, antifungal susceptibility test results, age, gender records were identified from Microbiology Laboratory Information Management System. Results: 97.4% of the isolates were Trichosporon asahii, and 2.6% were Trichosporon mucoides. The most frequent isolation period was the 2016 and 2019 year group (71.4%), not during the COVID-19 Pandemics (19.5%). The most common sample type was urine (58.4%), of whom predominantly (58.4%) hospitalized in the Intensive Care Unit. Amphotericin B MICs were ≤1µg/ml in 68.9% of the isolates. Fluconazole and voriconazole MICs were ≤1µg/ml in 20.0% and 94.8%, respectively. 59.7% of the isolates had a MIC of ≥4µg/ml for flucytosine. Micafungin and caspofungin MICs were ≥4µg/ml in 88.3% and 92.2% of the isolates, respectively. Voriconazole had the strongest in vitro activity, and amphotericin B had lower MICs than expected. The combination therapy of voriconazole and amphotericin B could be a therapeutic option in this setting, as well as monotherapy of voriconazole. Conclusion: Trichosporon spp. isolated in clinical specimens and their antifungal susceptibility depend on the geographic region and the anatomic site. Identifying local data will contribute to both the management of these patients, and surveillance studies.
临床分离毛孢菌的分布和抗真菌敏感性:10年的单中心研究经验
目的:毛孢菌属是一种类似酵母的担子菌,在自然界中普遍存在,是人类微生物群的一部分。这是一种机会性真菌病原体,曾经很罕见,但最近急剧增加,导致致命的感染。本研究的目的是确定临床分离的Trichosporon spp.菌株的流行率和抗真菌敏感性,并确定在COVID-19大流行期间发病率是否发生变化。& # x0D;材料和方法:这是一项回顾性横断面描述性研究,于2013年1月1日至2023年2月5日进行。筛选分离的Trichosporon sp .培养物(n=125),纳入符合条件的培养物(n=77)。鉴定、抗真菌药敏试验结果、年龄、性别记录在微生物实验室信息管理系统中进行鉴定。& # x0D;结果:97.4%的分离株为朝日毛磷菌,2.6%为粘液毛磷菌。最常见的隔离期是2016年和2019年组(71.4%),而不是COVID-19大流行期间(19.5%)。最常见的样本类型是尿液(58.4%),其中主要(58.4%)在重症监护病房住院。68.9%的分离株两性霉素B mic≤1µg/ml。氟康唑和伏立康唑的mic≤1µg/ml分别占20.0%和94.8%。59.7%的分离株氟胞嘧啶的MIC≥4µg/ml。Micafungin和caspofungin的mic≥4µg/ml的比例分别为88.3%和92.2%。伏立康唑的体外活性最强,两性霉素B的mic低于预期。伏立康唑和两性霉素B联合治疗可能是这种情况下的一种治疗选择,以及伏立康唑的单一治疗。 结论:临床标本中分离到的毛孢丝虫病的抗真菌敏感性与地理区域和解剖部位有关。确定当地数据将有助于这些患者的管理和监测研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cukurova Medical Journal
Cukurova Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
159
审稿时长
12 weeks
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