Effects of Combined Administration of Sulforaphane and Resveratrol on Orofacial Pain Control in Rats

Min-kyoung Park, Sae-hee Cheon, Kyung-min Kim, Hye-jin Kim, Min-kyung Lee
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 Methods: In this study, 5% formalin was injected into the face of the experimental animals to induce pain behavioral responses, and sulforaphane 15 μg or 150 μg/50 μl and resveratrol 20 μg or 200 μg/50 μl were pre-treated to confirm the pain control effects.
 Results: The two drugs showed pain-modifying effects in a concentration-dependent manner. In addition, a significant analgesic effect was confirmed when the two drugs were co-administered at low concentrations.
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Abstract

Objectives: This study was designed to confirm the effects of natural products on the control of facial pain. Methods: In this study, 5% formalin was injected into the face of the experimental animals to induce pain behavioral responses, and sulforaphane 15 μg or 150 μg/50 μl and resveratrol 20 μg or 200 μg/50 μl were pre-treated to confirm the pain control effects. Results: The two drugs showed pain-modifying effects in a concentration-dependent manner. In addition, a significant analgesic effect was confirmed when the two drugs were co-administered at low concentrations. Conclusions: Therefore, through this experiment, sulforaphane and resveratrol can be effective therapeutic agents for controlling orofacial pain.
萝卜硫素和白藜芦醇联合给药对大鼠口腔面部疼痛的控制作用
目的:本研究旨在证实天然产物对面部疼痛的控制作用。 方法:在实验动物面部注射5%福尔马林,诱导疼痛行为反应,并对萝卜硫素15 μg或150 μg/50 μl和白藜芦醇20 μg或200 μg/50 μl进行预处理,确认疼痛控制效果。结果:两种药物均表现出浓度依赖性的镇痛作用。此外,当两种药物在低浓度下共同给药时,证实了显著的镇痛作用。 结论:通过本实验,萝卜硫素和白藜芦醇可作为控制口面部疼痛的有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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