Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review
{"title":"Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review","authors":"Sabnam Parveen , Ritchu Babbar , Vishnu Nayak Badavath , Suman Kumar Nath , Sourabh Kumar , Ravi Rawat , Sridevi Chigurupati , Rohini Karunakaran , Pranay Wal , Monica Gulati , Tapan Behl","doi":"10.1080/00397911.2023.2269582","DOIUrl":null,"url":null,"abstract":"<div><p>The thiazolidinone component is a specialized frame exhibiting various biological reactions comprising analgesic, hypnotic, antiviral, anticancer, antitubercular, and many more. As the target scaffold for biological investigations, current category of heterocycles has been created by researchers using a number of fundamental techniques, as well as sophisticated routes. Recent research has focused heavily on 1,3-thiazolidin-4-one heterocyclic nuclei, which contain electron configurations at the tetrahedral site and at positions 1 and 3, sulfur and nitrogen atoms, respectively. The goal of the current review is to summarize the published work concerning the chemistry and pharmacological properties of thiazolidinone derivatives over the past few years. This is executed by characterizing thiazolidinone derivatives with various pharmacological activities using structural substitution patterns around the thiazolidinone moiety as the basis for the SAR study and their interactions with various proteins. This review also summarizes current developments in the chemical, molecular and biological activities of thiazolidinones.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791123003892","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The thiazolidinone component is a specialized frame exhibiting various biological reactions comprising analgesic, hypnotic, antiviral, anticancer, antitubercular, and many more. As the target scaffold for biological investigations, current category of heterocycles has been created by researchers using a number of fundamental techniques, as well as sophisticated routes. Recent research has focused heavily on 1,3-thiazolidin-4-one heterocyclic nuclei, which contain electron configurations at the tetrahedral site and at positions 1 and 3, sulfur and nitrogen atoms, respectively. The goal of the current review is to summarize the published work concerning the chemistry and pharmacological properties of thiazolidinone derivatives over the past few years. This is executed by characterizing thiazolidinone derivatives with various pharmacological activities using structural substitution patterns around the thiazolidinone moiety as the basis for the SAR study and their interactions with various proteins. This review also summarizes current developments in the chemical, molecular and biological activities of thiazolidinones.
期刊介绍:
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.