PHYSICOCHEMICAL PROPERTIES, GC-MS ANALYSIS, AND ANTIBACTERIAL ASSAY OF Citrus limon PEELS ESSENTIAL OIL AGAINST ANTIBIOTIC RESISTANT Escherichia Coli

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1638442

Nur Ain Khairunnisa, None Yuandani, Abdi Wira Septama, Sony Eka Nugraha, None Sufitni

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引用次数: 0

Abstract

Essential oils (EOs) produced naturally by plants have been used as antimicrobial agents despite the majority of compounds have not been studied. The study was conducted to assess the effect of EOs found in Citrus limon peels against antibiotic resistance of E. coli by quantifying the specific gravity, refractive index, and GC-MS. The result of GC-MS presented that D-limonene, α-citral, and β-citral are the major constituents of C. limon EO, presenting 56.85; 13.24; and 10.40% of the oil content, respectively. Tests on the essential oil of C. limon confirm its potential antibacterial activity. This assertion was supported by the MIC and MBC values obtained at 250 μg/mL and 500 μg/mL, respectively. Meanwhile, tetracycline showed identical MIC and MBC at 125 μg/mL. The interaction between essential oil and tetracycline was evaluated using a checkerboard assay. Moreover, C. limon peels essential oil had a synergistic to decrease biofilm formation in bacterial tested . In addition, the combination of C. limon peels essential oil and tetracycline illustrated potential activities to lysis the cells and inhibit the efflux pumps of E. coli. The result suggests the combination of C. limon peels essential oil and tetracycline could be used to eradicate antibiotic-resistant E. coli.

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.