Unveiling Therapeutic Potential: A Systematic Review of Photobiomodulation Therapy and Biological Dressings for Diabetic Foot Ulcers

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of lasers in medical sciences Pub Date : 2023-10-28 DOI:10.34172/jlms.2023.49

Sina Karimpour, Mohammad Hussein Amirmotamed, Fariborz Rashno, Foozhan Tahmasebinia, Aliasghar Keramatinia, Fatemeh Fadaee Fathabadi, Hojjat Allah Abbaszadeh, Shahram Darabi

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引用次数: 0

Abstract

Introduction: Diabetes poses a global health challenge, giving rise to various complications, including diabetic foot ulcers (DFUs). DFUs, marked by ischemic ulcers susceptible to infection and amputation, underscore the urgency for innovative treatments. This study investigated the impact of photobiomodulation therapy (PBT) and autologous platelet gel (APG) on DFUs recovery. Methods: We systematically searched Web of Science, EMBASE, MEDLINE, Cochrane Library, Scopus, and Google Scholar (2015-2023) by using pertinent terms like "photobiomodulation therapy," "low level light therapy," and "platelet gel." After meticulous data extraction and review, 57 articles were chosen and categorized. Among these, three randomized controlled trials involving 186 participants were selected for APG analysis. Results: Findings demonstrate that APG application carries minimal risk and offers promising improvements in healing time, grade, pain reduction, and granulation tissue formation. Similarly, diverse PBT modalities involving distinct probes and wavelengths exhibit the potential to enhance tissue perfusion, expedite healing, and impede wound progression, reducing the need for invasive interventions. Conclusion: PBT and APG emerge as valuable tools to augment wound healing, mitigate inflammation, and avert amputation, representing compelling therapeutic options for DFUs.

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揭示治疗潜力:糖尿病足溃疡的光生物调节疗法和生物敷料的系统综述

糖尿病是一个全球性的健康挑战，引起各种并发症，包括糖尿病足溃疡(DFUs)。DFUs以易感染和截肢的缺血性溃疡为特征，强调了创新治疗的紧迫性。本研究探讨了光生物调节治疗(PBT)和自体血小板凝胶(APG)对DFUs恢复的影响。方法:系统检索Web of Science、EMBASE、MEDLINE、Cochrane Library、Scopus、Google Scholar(2015-2023)，检索相关词汇如“光生物调节疗法”、“低水平光疗法”、“血小板凝胶”。经过细致的数据提取和审查，选出了57篇文章并进行了分类。其中选取3项随机对照试验186名受试者进行APG分析。结果:研究结果表明，应用APG风险最小，并且在愈合时间、愈合程度、疼痛减轻和肉芽组织形成方面有希望改善。同样，涉及不同探针和波长的多种PBT模式显示出增强组织灌注、加速愈合和阻碍伤口进展的潜力，减少了侵入性干预的需要。结论:PBT和APG是促进伤口愈合、减轻炎症和避免截肢的有价值的工具，代表了对DFUs的令人信服的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of lasers in medical sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

3.00

自引率

13.30%

发文量

期刊介绍： The "Journal of Lasers in Medical Sciences " is a scientific quarterly publication of the Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences. This journal received a scientific and research rank from the national medical publication committee. This Journal accepts original papers, review articles, case reports, brief reports, case series, photo assays, letters to the editor, and commentaries in the field of laser, or light in any fields of medicine such as the following medical specialties: -Dermatology -General and Vascular Surgery -Oncology -Cardiology -Dentistry -Urology -Rehabilitation -Ophthalmology -Otorhinolaryngology -Gynecology & Obstetrics -Internal Medicine -Orthopedics -Neurosurgery -Radiology -Pain Medicine (Algology) -Basic Sciences (Stem cell, Cellular and Molecular application and physic)