Therapeutic Implications of PTEN Loss in Patients with Cowden Syndrome and Renal Cell Cancer

Q4 Medicine

Surgery, Gastroenterology and Oncology Pub Date : 2023-01-01 DOI:10.21614/sgo-588

Katia Lanzafame, Nicola Inzerilli, Rosaria Carciotto, Claudio Longhitano, Stefania Stella, Lo Bianco Salvatore, Lorenzo Rossi, Paolo Vigneri

引用次数: 0

Abstract

Purpose: Patients with Cowden syndrome (CS) have an increased lifetime risk of developing cancers, particularly breast, uterus, thyroid, colon and renal cell cancer. CS is associated with a germline mutation of PTEN, a gene that plays an important role in carcinogenesis. This review hypothesized that inactivation of PTEN could have dramatic consequences on response of treatments in patients with Cowden Syndrome.

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PTEN缺失在考登综合征和肾细胞癌患者中的治疗意义

目的:考登综合征(CS)患者一生中患癌症的风险增加，尤其是乳腺癌、子宫癌、甲状腺癌、结肠癌和肾癌。CS与PTEN基因的种系突变有关，PTEN基因在癌变中起重要作用。本综述假设PTEN的失活可能对考登综合征患者的治疗反应产生显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery, Gastroenterology and Oncology Medicine-Gastroenterology

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： Starting with this issue "Annals of Fundeni Hospital", founded in 1996 as the scientific journal of the prestigious hospital Fundeni becomes "Journal of Translational Medicine and Research" (JTMR), an Journal of the Academy of Medical Sciences of Romania. Therefore, an 18 years old Journal, attested and indexed in Elsevier Bibliographic Databases, Amsterdam and also indexed in SCOPUS, is continuing a tradition of excellence that lasted almost two decades. The new title of the Journal is inspired first of all from the important developments of translational research In Fundeni Clinical Institute and the "C.C Iliescu Institute for Cardio-Vascular Diseases", in parallel with the national and international trend to promote and develop this important area or medical research. Although devoted mainly to translational research, JTMR will continue to promote both basic and clinical research.