Clinical Manifestations and Prognostic Factors of Ocular Infection Associated with Orbital or Preseptal Cellulitis

IF 0.1 Q4 OPHTHALMOLOGY
Hyun Jee Kim, Yong-Sok Ji, Kyung Chul Yoon, Hyeon-Jeong Yoon
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Abstract

Purpose: We assessed the clinical manifestations and prognostic factors associated with ocular infection in patients diagnosed with orbital and preseptal cellulitis.Methods: We enrolled 40 patients diagnosed with ocular infection accompanied by orbital and preseptal cellulitis between October 2015 and December 2021. We divided patients into the “treatment success group” (patients whose infection resolved) and the “treatment failure group” (patients whose infection worsened and required evisceration). Clinical characteristics, such as infection-related ocular findings and microbiological features, were analyzed retrospectively in both groups. Chi-square tests and logistic regression analyses were performed to identify prognostic factors associated with treatment failure.Results: The mean age of patients was 72.8 ± 11.92 years, with 17 (42.5%) of them being male. Among the patients, 11 had bacterial infections, and 3 had fungal infections. In total, 6 (15%) and 34 (85%) patients were classified into the treatment success and failure groups, respectively. The chi-square test revealed a significant association between the treatment failure group and several clinical factors, such as low best corrected visual acuity (BCVA), the logarithm of the minimum angle resolution (logMAR) BCVA > 2, low intraocular pressure (IOP) < 5 mmHg, large size of the corneal lesion, and the presence of hypopyon (p < 0.05). Furthermore, the multivariate logistic regression analysis identified hypopyon as a significant risk factor for treatment failure (p = 0.036).Conclusions: A significantly high treatment failure rate of 85% was observed in patients with ocular infections accompanied by orbital and preseptal cellulitis. Several clinical factors, such as low BCVA with logMAR BCVA > 2, IOP < 5 mmHg, large size of the corneal lesion, and a prolonged duration of symptoms demonstrated significant association with treatment failure. Notably, hypopyon is an important prognostic factor for treatment failure.
眼眶或鼻中隔蜂窝织炎相关眼部感染的临床表现及预后因素分析
目的:评估眼眶和隔膜前蜂窝织炎患者的临床表现和与眼部感染相关的预后因素。方法:我们在2015年10月至2021年12月期间招募了40例诊断为眼部感染并伴有眼眶和隔膜蜂窝织炎的患者。我们将患者分为“治疗成功组”(感染解决的患者)和“治疗失败组”(感染恶化并需要切除内脏的患者)。回顾性分析两组患者的临床特征,如感染相关的眼部表现和微生物学特征。卡方检验和逻辑回归分析确定与治疗失败相关的预后因素。结果:患者平均年龄72.8±11.92岁,男性17例(42.5%)。其中细菌感染11例,真菌感染3例。治疗成功组6例(15%),治疗失败组34例(85%)。卡方检验显示治疗失败组与低最佳矫正视力(BCVA)、最小角度分辨力(logMAR)的对数BCVA >2、低眼压(IOP);5毫米汞柱,角膜病变大,存在低血压(p <0.05)。此外,多因素logistic回归分析发现,假说是治疗失败的重要危险因素(p = 0.036)。结论:眼部感染合并眶前蜂窝织炎患者的治疗失败率高达85%。几个临床因素,如低BCVA与logMAR BCVA >2、IOP <5mmhg,角膜病变面积大,症状持续时间长,与治疗失败显著相关。值得注意的是,假说是治疗失败的重要预后因素。
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CiteScore
0.20
自引率
0.00%
发文量
126
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