Recovery from Upper Eyelid Sulcus Deepening Following Switch from Prostaglandin Analogues to EP2 Receptor Agonist

IF 0.1 Q4 OPHTHALMOLOGY
Young Joon Jeon, Jong Jin Jung
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Abstract

Purpose: To report a case of recovery from deepening of the upper eyelid sulcus after switching from prostaglandin FP receptor agonists to an EP2 receptor agonist.Case summary: A 65-year-old male patient with suspicion of glaucoma presented for detailed examinations. At the initial visit, his best-corrected visual acuity was 1.0 in both eyes, and the intraocular pressure (IOP) was 14/14 mmHg. Examination revealed no specific findings in the anterior segment, mild early cataracts bilaterally, and moderate glaucomatous changes. Therefore, bimatoprost/timolol fixed-combination eye drops were administered in both eyes. After 1 month, the IOP was 11/11 mmHg and no evidence of glaucoma progression was found. After 10 months, the IOP was 17/18 mmHg and there was deepening of the upper eyelid sulcus bilaterally. Consequently, bimatoprost/timolol fixed combination eye drops were switched to omidenepag isopropyl. Within 2 months of the switch, the deepening of the upper eyelid sulcus recovered completely and the IOP was 14/13 mmHg.Conclusions: Patients with prostaglandin-associated periorbitopathy should be switched to non-prostaglandin drugs or EP2 receptor agonists. Our patient exhibited complete recovery of the upper eyelid sulcus deepening after switching to an EP2 agonist.
前列腺素类似物转换为EP2受体激动剂后上睑沟加深的恢复
目的:报告一例从前列腺素FP受体激动剂转换为EP2受体激动剂后,从上睑沟加深恢复。病例总结:65岁男性患者,怀疑为青光眼,提出详细检查。初次就诊时,双眼最佳矫正视力1.0,眼压14/14 mmHg。检查未见前段特殊病变,轻度早期双侧白内障,中度青光眼改变。因此,双眼使用比马前列素/替马洛尔固定联合滴眼液。1个月后,IOP为11/11 mmHg,无青光眼进展迹象。10个月后,IOP为17/18 mmHg,双侧上睑沟加深。因此,bimatoprost/timolol固定联合滴眼液切换为omidenepag异丙基。转换后2个月内,上睑沟深度完全恢复,IOP为14/13 mmHg。结论:前列腺素相关性眼周病变患者应改用非前列腺素类药物或EP2受体激动剂。在改用EP2激动剂后,我们的患者表现出上睑沟加深的完全恢复。
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来源期刊
CiteScore
0.20
自引率
0.00%
发文量
126
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