Matrix Metalloproteinases 9 Testing Using Immunoassay Kit in Oculoplastic Outpatient Clinic Patients

IF 0.1 Q4 OPHTHALMOLOGY
Wan kyu Choi, Jung woo Park, Jisang Han
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Abstract

Purpose: We assessed the association between the results of tear film-based matrix metalloproteinases 9 (MMP-9) immunoassay and the diagnosis of patients who visited an oculoplastic outpatient clinic.Methods: We conducted a retrospective analysis of the MMP-9 immunoassay results in 1,703 eyes from 1,703 patients who presented with ocular discomfort at an oculoplastic outpatient clinic. The MMP-9 immunoassay results were analyzed in correlation with the final oculoplastic diagnosis of the patients.Results: In total, 1,126 of 1,533 eyes demonstrated positive expression of MMP-9. No statistically significant differences were observed in MMP-9 expression based on sex (p = 0.107) and age (p = 0.510). Furthermore, 120 of 169 eyes with thyroid eye disease (71.0%, p < 0.001), 145 of 161 eyes with nasolacrimal duct obstruction (90.1%, p < 0.001), 282 of 375 eyes with nasolacrimal duct stenosis (75.2%, p < 0.001), 190 of 238 eyes with entropion (79.8%, p < 0.001), 19 of 23 eyes with ectropion (82.6%, p < 0.001), and 370 of 567 eyes with dry eye syndrome (65.3%, p < 0.001) exhibited positive MMP-9 expression.Conclusions: The MMP-9 immunoassay is a noninvasive, convenient, and rapid test that evaluates ocular surface inflammation. Most patients with oculoplastic diseases exhibit positive MMP-9 expression. These findings provide valuable information for guiding diagnostic and management decisions in patients with oculoplastic conditions.
免疫分析法检测基质金属蛋白酶9在眼科整形门诊患者中的应用
目的:我们评估泪膜基质金属蛋白酶9 (MMP-9)免疫测定结果与就诊于眼科门诊的患者的诊断之间的关系。方法:我们对在眼科整形门诊就诊的1703例出现眼部不适的患者的1703只眼睛的MMP-9免疫分析结果进行了回顾性分析。分析MMP-9免疫分析结果与患者最终的眼部整形诊断的相关性。结果:1533眼中MMP-9阳性表达1126眼。MMP-9在性别(p = 0.107)和年龄(p = 0.510)之间的表达差异无统计学意义。此外,169只眼中有120只眼患有甲状腺眼病(71.0%,p <0.001), 145 / 161眼鼻泪管梗阻(90.1%,p <0.001), 375只眼中282只出现鼻泪管狭窄(75.2%,p <0.001), 238只眼中有190只眼内翻(79.8%,p <0.001), 23只眼中有19只眼外翻(82.6%,p <567只眼中有370只出现干眼综合征(65.3%,p <0.001) MMP-9表达阳性。结论:MMP-9免疫分析法是一种无创、方便、快速的评估眼表炎症的方法。大多数眼成形性疾病患者表现为MMP-9阳性表达。这些发现为指导眼部成形性疾病患者的诊断和管理决策提供了有价值的信息。
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来源期刊
CiteScore
0.20
自引率
0.00%
发文量
126
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