Retrospective Analysis of the Efficacy and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Korean Patients

IF 0.1 Q4 OPHTHALMOLOGY
Hansang Lee, Sang Yeop Lee, Hyoung Won Bae, Chan Yun Kim, Wungrak Choi
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引用次数: 0

Abstract

Purpose: This study aimed to analyze the clinical efficacy and safety of omidenepag isopropyl (OMDI) 0.002% in Korean patients.Methods: A retrospective study was conducted involving 306 patients diagnosed with glaucoma or ocular hypertension, who were administered OMDI 0.002% from May 2021 to June 2022. The primary outcomes were the change in intraocular pressure (IOP) at months 1, 3, and 6 compared to the baseline IOP, and the reactions to the OMDI drug.Results: Out of 235 patients who met the study inclusion criteria, the mean IOP was 16.5 ± 3.4 mmHg at baseline, 14.5 ± 3.0 mmHg at month 1, 14.3 ± 2.7 mmHg at month 3, and 14.7 ± 3.1 mmHg at month 6. The mean IOP reduction at month 6 was -1.6 ± 2.8 mmHg (p < 0.001). On analyzing the IOP by types of glaucoma, the mean IOP change at the 6-month point showed statistically significant results in all types, including normal tension glaucoma, primary open-angle glaucoma, and ocular hypertension (p < 0.05). The frequency of side effects in all patients was 29.8%, with the most commonly reported adverse drug reaction being hyperemia in 18.7% of the total patients. There was one case (0.4%) of uveitis after OMDI administration, but no other systemic adverse drug reactions were reported.Conclusions: Omidenepag isopropyl demonstrated a statistically significant IOP-lowering effect in Korean patients with various types of glaucoma. This suggests that OMDI could potentially serve as a first-line treatment for glaucoma.
0.002%异丙基奥米尼帕格眼液在韩国患者中的疗效和安全性回顾性分析
目的:本研究旨在分析0.002%奥米尼帕格异丙基(OMDI)在韩国患者中的临床疗效和安全性。方法:对306例诊断为青光眼或高眼压的患者进行回顾性研究,这些患者于2021年5月至2022年6月接受0.002%的OMDI治疗。主要结局是第1、3和6个月时眼压(IOP)与基线IOP相比的变化,以及对OMDI药物的反应。结果:在235例符合研究纳入标准的患者中,平均IOP基线时为16.5±3.4 mmHg,第1个月时为14.5±3.0 mmHg,第3个月时为14.3±2.7 mmHg,第6个月时为14.7±3.1 mmHg。第6个月的平均IOP降低为-1.6±2.8 mmHg (p <0.001)。对不同类型青光眼的IOP进行分析,6个月时所有类型的平均IOP变化均有统计学意义,包括正常紧张性青光眼、原发性开角型青光眼和高眼压(p <0.05)。所有患者副反应发生率为29.8%,其中最常见的药物不良反应为充血,占总患者的18.7%。用药后出现葡萄膜炎1例(0.4%),未见其他全身药物不良反应。结论:奥米尼帕格异丙酯对韩国不同类型青光眼患者的降眼压效果具有统计学意义。这表明OMDI有可能成为青光眼的一线治疗方法。
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来源期刊
CiteScore
0.20
自引率
0.00%
发文量
126
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