Effect of parasite infection on IgE, Anti-TG, Anti-TPO of thyroiditis patients

Abstract

This study was conducted to investigate parasitic infection's effect on the thyroid gland's functions by hypo- or hyperthyroidism and inflammation by measuring some physiological and immunological indicators. 130 blood and stool samples were collected from both genders, including 80 samples from people with thyroid disorders and 50 samples from healthy people. Anti-TG, anti-TPO and IgE were estimated by using the Cobas e411 device. The general stool examination was carried out to confirm the presence of a parasitic infection and determine the type of parasites. The type of parasites found the most affected were Entamoeba histolytica, Giardia lamblia, Blastocystis hominis, and the last parasite, Cryptosporidium. Anti-TG, anti-TPO, and IgE immunoassays significantly increased hypo and hyperthyroidism cases compared to the control. The increase was higher in parasitic-infected patients than in non-infected patients compared to the control. Results of the infected were as follows: (94.41, 27.96, 361.44) IU/ml and (54.13, 18.48, 308.18) IU/ml, for non-infected (55.46, 18.48, 149.67) IU/ml and (89.56, 20.80, 90.67) IU/ml. Compared to the control (22.3, 7.05, 62.93) IU/ml, respectively. Conclusion: This study showed that infection with a parasite affected the performance of the thyroid gland. Keywords: Parasites; Thyroid Disorders; Anti-TG; Anti-TPO; IgE.