An Awareness of Pharmacovigilance among Healthcare Professionals Due to an Underreporting of Adverse Drug Reactions Issue: A Systematic Review of the Current State, Obstacles, and Strategy

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-16 DOI:10.2174/0115748863276456231016062628

Risani Andalasia Putri, Zullies Ikawati, Fita Rahmawati, Nanang Munif Yasin

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引用次数: 0

Abstract

Background: Healthcare professionals play an essential role in reporting adverse drug reactions as part of pharmacovigilance activities. However, adverse drug reactions reported by healthcare professionals remain low. Objective: The aim of this systematic review was to investigate healthcare professionals' knowledge, awareness, attitude, and practice on pharmacovigilance and adverse drug reaction reporting, explore the causes of the underreporting issue, and provide improvement strategies. Methods: This systematic review was conducted using four electronic databases for original papers, including PubMed, Scopus, Google Scholar, and Scholar ID. Recent publications from 1st January 2012 to 31st December 2022 were selected. The following terms were used in the search: "awareness", "knowledge", "adverse drug reaction", "pharmacovigilance", "healthcare professional", and "underreporting factor". Articles were chosen, extracted, and reviewed by the two authors. Results: Twenty-five studies were selected for systematic review. This review found that 24.8%–73.33% of healthcare professionals were unaware of the National Pharmacovigilance Center. Around 20%–95.7% of healthcare professionals have a positive attitude toward pharmacovigilance and adverse drug reaction reporting, while 12%–60.8% of healthcare professionals have experience reporting any adverse drug reaction in their practice. The most frequently highlighted barriers to pharmacovigilance were a lack of awareness and knowledge regarding what, when, and to whom to report. Conclusion: Underreporting issues require immediate attention among healthcare professionals due to a lack of awareness and knowledge of pharmacovigilance and adverse drug reaction reporting. Educational and training program interventions have been suggested by most studies to address these issues.

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由于药物不良反应少报问题，医疗保健专业人员的药物警戒意识:对现状、障碍和策略的系统回顾

背景:作为药物警戒活动的一部分，卫生保健专业人员在报告药物不良反应方面发挥着至关重要的作用。然而，卫生保健专业人员报告的药物不良反应仍然很低。目的:本系统评价旨在调查卫生保健专业人员对药物警戒和药物不良反应报告的知识、意识、态度和实践情况，探讨漏报问题的原因，并提出改进策略。方法:采用PubMed、Scopus、Google Scholar、Scholar ID等4个电子原始论文数据库进行系统评价。选取2012年1月1日至2022年12月31日的近期出版物。搜寻时使用的主题词包括:“认知”、“知识”、“药物不良反应”、“药物警戒”、“医护人员”及“少报因素”。文章由两位作者选择、摘录和审阅。结果:选取25项研究进行系统评价。本综述发现24.8%-73.33%的卫生保健专业人员不知道国家药物警戒中心。约20%-95.7%的医护人员对药物警戒和药物不良反应报告持积极态度，12%-60.8%的医护人员在执业过程中有报告药物不良反应的经历。最常见的药物警戒障碍是缺乏对报告什么、何时报告和向谁报告的认识和知识。结论:由于缺乏药物警戒和药物不良反应报告的意识和知识，低报问题需要立即引起卫生保健专业人员的注意。大多数研究都建议采取教育和培训计划干预措施来解决这些问题。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.