Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on Medical Information Mart for Intensive Care database: A cross-sectional study

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-08-30 DOI:10.5937/jomb0-45219

Zihan Jin, Lu Xiao, Xinyi Xu, Changhong Miao, Yi Liu

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引用次数: 0

Abstract

Background: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two. Methods: Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model. Results: Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk (odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P < 0.001). Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk (OR = 2.99, 95% CI = 1.64 to 5.46, P < 0.001). The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313). Conclusion: In patients with AMI, the incidence of TyG and AKI is closely related. Nevertheless, further studies are needed to verify the finding.

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基于重症监护医学信息集市数据库的急性心肌梗死患者甘油三酯-葡萄糖指数与急性肾损伤的相关性横断面研究

背景:急性心肌梗死(AMI)患者甘油三酯葡萄糖(TyG)指数与急性肾损伤(AKI)发生率的关系尚不清楚。本研究旨在探讨两者之间的关系。方法:从重症监护医学信息市场(MIMICIV)中招募受试者，根据TyG指数的四分位数区间对受试者进行分组。以AKI的存在为主要结果，构建logistic回归模型。使用限制三次样条(RCS)模型检验了TyG指数与所得结果的相关性。结果:1101例AMI患者中，男性占64.7%，AKI总发病率为37.1%。多因素Logistic回归分析(LRA)结果显示TyG指数与AKI风险增加存在独立相关性(优势比(OR) = 2.23;置信区间(CI) = 1.59 ~ 3.17;P & lt;0.001)。TyG指数四分位数中的Q4(9.5-12.208)与AKI风险增加独立相关(OR = 2.99, 95% CI = 1.64 ~ 5.46, P <0.001)。RCS模型显示，随着TyG指数的增加，AKI风险呈线性增加(P=0.313)。结论:在AMI患者中，TyG与AKI的发生率密切相关。然而，需要进一步的研究来证实这一发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.