Shared immune metabolic reprogramming between COVID-19 patients in the intensive care unit and ischemic stroke: a pilot study

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2023-10-30 DOI:10.5114/aoms/172161

Jie Li, Fushen Li, Bin He, Cong Yu, Ping Zheng

引用次数: 0

Abstract

Introduction To investigate shared gene signatures between COVID-19 and ischemic stroke. Material and methods Combining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism. Results A total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways. Conclusions Our study revealed the common molecular profile of COVID-19 and ischemic stroke.

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重症监护病房COVID-19患者与缺血性卒中患者共享免疫代谢重编程:一项试点研究

目的探讨新冠肺炎与缺血性脑卒中的共同基因特征。材料和方法结合现有的COVID-19大体积RNA测序和单细胞RNA测序(scRNA-seq)数据，更全面地了解代谢失调的作用。结果共筛选出19个差异表达上调基因(DEGs)和24个差异表达下调基因(DEGs)进行后续分析。最终用机器学习方法确定了9个基因，作为缺血性卒中和COVID-19的潜在诊断模型。此外，枢纽基因与免疫浸润和代谢途径均有关。结论我们的研究揭示了COVID-19与缺血性卒中的共同分子特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.