Adrenoleukodystrophy/Adrenomyeloneuropathy and Neurogenic Bladder Dysfunction. A Review

Abstract

One of the conditions associated with adrenoleukodystrophy (ALD) / adrenomyeloneuropathy (AMN) is neurogenic lower urinary tract dysfunction (LUTD). A thorough examination of patients with ALD/AMN in most cases can reveal overactive bladder (OAB), which often remains undiagnosed because its clinical manifestations are underestimated against the background of numerous neurologic symptoms. In addition, in some cases, urologic symptomatology is the first sign of ALD/AMN that prompts the urologist to consider further evaluation of the patient. In this case, the urologist can play a significant role in the patient’s life, as timely diagnosis and treatment of ALD/AMN improve disease outcomes and reduce the likelihood of complications of ALD/AMN-associated conditions. To date, there are few studies devoted to the understanding of LUTD in ALD/AMN. In this article, we reviewed the current literature on OAB in patients with ALD/AMN.