Biliary refl ux gastritis: features of pathogenesis, diagnostics and treatment

Abstract

The article discusses the controversial terminology of biliary refl ux gastritis and the factors predisposing to its occurrence. Pathogenesis of this disease includes 2 main components: disorders of motility of the stomach and duodenum, leading to duodeno-gastric refl ux, and direct damaging eff ect of hydrophobic bile acids and lysolecithin on the protective barrier of the stomach mucosa. Clinical picture of biliary refl ux gastritis is nonspecifi c and most often corresponds to dyspepsia syndrome. Esophagogastroduodenoscopy with biopsy and subsequent histological examination, 24-hour pH-metry of the stomach, monitoring of bilirubin level in gastric contents are used in diagnostics of this disease. Treatment of biliary refl ux gastritis includes prescription of ursodeoxycholic acid, prokinetics, antacids, proton pump inhibitors, cytoprotectors. Given the insuffi cient study and controversial coverage of many aspects of biliary refl ux gastritis, this problem requires further research.