Origanum Compactum Essential Oil Ameliorates Triton WR-1339-Induced Hyperlipidemia in Rats: Chemical Composition and Acute Toxicity

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-10-17 DOI:10.1080/10496475.2023.2269888

Ayoub Amssayef, Bouchra Soulaimani, Adil Qabouche, Abdelaziz Abbad, Mohamed Eddouks

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Abstract

ABSTRACTThe impact of Origanum compactum essential oil (EO) at 80 mg kg−1 on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO’s phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli’s risk index I (CRI-I), and Castelli’s risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.KEYWORDS: Antihyperlipidemic effectmedicinal plantstoxicityLD50 Disclosure statementNo potential conflict of interest was reported by the author(s).Ethics ApprovalAll experiments were performed according to the local ethical committee, Faculty of Science and Techniques Errachidia, Morocco, number FSTE/2015.Abbreviations AC=Atherogenic coefficientCRI=Castelli’s risk indexEO=Essential oilHDL-C=High-density lipoprotein cholesterolHMG-CoA reductase=Hydroxymethyl-glutaryl coenzyme A reductaseLDL-C=Low-density lipoprotein cholesterolTC=Total cholesterolTGs=TriglyceridesVLDL-C=Very-low-density lipoprotein cholesterolAdditional informationFundingThis work was supported by the CNRST under grant N° PPR/2015/35.

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薄荷叶精油改善Triton wr -1339诱导的大鼠高脂血症:化学成分和急性毒性

摘要本文研究了80 mg kg -1莪术精油对Triton wr -1339诱导的大鼠高脂血症的影响。植物化学成分以香芹酚(35.71%)、对花香烃(13.74%)和香芹酚甲醚(11.71%)为主。Triton WR-1339导致总胆固醇(TC)、甘油三酯(tg)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)升高，以及包括致动脉粥样硬化系数(AC)、Castelli风险指数I (CRI-I)和Castelli风险指数II (CRI-II)在内的致动脉粥样硬化指标升高。相反，用O. Compactum EO预处理7 d对TC、tg、LDL-C、VLDL-C、AC、cri的升高有预防作用。关键词:降血脂作用;药用植物;毒性;所有实验均按照摩洛哥埃拉奇迪亚科学与技术学院当地伦理委员会的规定进行，编号FSTE/2015。缩写AC=动脉粥样硬化系数cri =Castelli 's风险指数eo =香精油hdl - c =高密度脂蛋白胆固醇hmg - coa还原酶=羟甲基-戊二酰辅酶A还原酶eldl - c =低密度脂蛋白胆固醇tc =总胆固醇tg =甘油三酯vldl - c =极低密度脂蛋白胆固醇经费来源本研究由CNRST资助，项目编号PPR/2015/35。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.