Hydroxychloroquine-induced generalized myopathy in a patient with lupus tumidus: a case report

IF 2.3 Q2 DERMATOLOGY
Alice Verdelli, Daniela Massi, Vincenza Maio, Gabriele Cavazza, Alberto Corrà, Elena Biancamaria Mariotti, Lavinia Quintarelli, Valentina Ruffo Di Calabria, Cristina Aimo, Emiliano Antiga, Marzia Caproni
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引用次数: 0

Abstract

Lupus erythematosus tumidus (LET) is a subset of cutaneous lupus erythematosus that generally presents with urticaria-like papules and plaques located on sun-exposed areas. Systemic treatment with antimalarials, especially hydroxychloroquine (HCQ), is the first-line systemic therapy for LET. Even if these drugs have a safe profile, side effects such as retinal toxicity, maculopapular rash, gastrointestinal upset, hemolytic anemia and blue-gray discoloration of the skin or the mucous membranes, have been rarely reported in the literature. Herein, we describe a rare case of a 46-year-old smoking woman with LET who developed a generalized myopathy after HCQ treatment.
羟氯喹致狼疮患者全身肌病1例报告
红斑狼疮(LET)是皮肤红斑狼疮的一个亚型,通常表现为荨麻疹样丘疹和斑块位于阳光照射区域。抗疟药的全身治疗,特别是羟氯喹(HCQ),是治疗LET的一线全身治疗。即使这些药物是安全的,副作用,如视网膜毒性,黄斑丘疹,胃肠道不适,溶血性贫血和皮肤或粘膜的蓝灰色变色,也很少在文献中报道。在此,我们描述一个罕见的病例,46岁吸烟女性LET谁发展了全身性肌病后,HCQ治疗。
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来源期刊
Dermatology Reports
Dermatology Reports DERMATOLOGY-
CiteScore
1.40
自引率
0.00%
发文量
74
审稿时长
10 weeks
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