Revisiting the relationship between complement and ulcerative colitis

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Yujie Ma, Kaicheng Zhang, Yuanyuan Wu, Xiaoyan Fu, Shujuan Liang, Meiyu Peng, Juntang Guo, Meifang Liu
{"title":"Revisiting the relationship between complement and ulcerative colitis","authors":"Yujie Ma, Kaicheng Zhang, Yuanyuan Wu, Xiaoyan Fu, Shujuan Liang, Meiyu Peng, Juntang Guo, Meifang Liu","doi":"10.1111/sji.13329","DOIUrl":null,"url":null,"abstract":"Abstract Ulcerative colitis (UC) is an inflammatory bowel disorder (IBD) characterized by relapsing chronic inflammation of the colon that causes continuous mucosal inflammation. The global incidence of UC is steadily increasing. Immune mechanisms are involved in the pathogenesis of UC, of which complement is shown to play a critical role by inducing local chronic inflammatory responses that promote tissue damage. However, the function of various complement components in the development of UC is complex and even paradoxical. Some components (e.g. C1q, CD46, CD55, CD59, and C6) are shown to safeguard the intestinal barrier and reduce intestinal inflammation, while others (e.g. C3, C5, C5a) can exacerbate intestinal damage and accelerate the development of UC. The complement system was originally thought to function primarily in an extracellular mode; however, recent evidence indicates that it can also act intracellularly as the complosome. The current study provides an overview of current studies on complement and its role in the development of UC. While there are few studies that describe how intracellular complement contributes to UC, we discuss potential future directions based on related publications. We also highlight novel methods that target complement for IBD treatment.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"1 1","pages":"0"},"PeriodicalIF":4.1000,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian Journal of Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/sji.13329","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract Ulcerative colitis (UC) is an inflammatory bowel disorder (IBD) characterized by relapsing chronic inflammation of the colon that causes continuous mucosal inflammation. The global incidence of UC is steadily increasing. Immune mechanisms are involved in the pathogenesis of UC, of which complement is shown to play a critical role by inducing local chronic inflammatory responses that promote tissue damage. However, the function of various complement components in the development of UC is complex and even paradoxical. Some components (e.g. C1q, CD46, CD55, CD59, and C6) are shown to safeguard the intestinal barrier and reduce intestinal inflammation, while others (e.g. C3, C5, C5a) can exacerbate intestinal damage and accelerate the development of UC. The complement system was originally thought to function primarily in an extracellular mode; however, recent evidence indicates that it can also act intracellularly as the complosome. The current study provides an overview of current studies on complement and its role in the development of UC. While there are few studies that describe how intracellular complement contributes to UC, we discuss potential future directions based on related publications. We also highlight novel methods that target complement for IBD treatment.

Abstract Image

补体与溃疡性结肠炎的关系
溃疡性结肠炎(UC)是一种炎症性肠病(IBD),其特征是结肠慢性炎症复发,导致持续的粘膜炎症。UC的全球发病率正在稳步上升。UC的发病机制涉及免疫机制,其中补体通过诱导局部慢性炎症反应促进组织损伤发挥关键作用。然而,各种补体成分在UC发展中的作用是复杂的,甚至是矛盾的。一些成分(如C1q、CD46、CD55、CD59、C6)具有保护肠道屏障、减轻肠道炎症的作用,而另一些成分(如C3、C5、C5a)可加重肠道损伤,加速UC的发展。补体系统最初被认为主要以细胞外模式起作用;然而,最近的证据表明,它也可以作为细胞内的复合物。本研究综述了目前关于补体及其在UC发展中的作用的研究。虽然很少有研究描述细胞内补体如何促进UC,但我们根据相关出版物讨论了潜在的未来方向。我们还强调了靶向补体治疗IBD的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信