Cell-Free Fetal DNA for Genetic Evaluation in Copenhagen Pregnancy Loss Study (COPL): A Prospective Cohort Study

IF 4.3 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Obstetrical & Gynecological Survey Pub Date : 2023-06-01 DOI:10.1097/ogx.0000000000001163

Tanja Schlaikjær Hartwig, Louise Ambye, Jennifer R. Gruhn, Jesper Friis Petersen, Tine Wrønding, Letizia Amato, Andrew Chi-Ho Chan, Boyang Ji, Maiken Hemme Bro-Jørgensen, Lene Werge, Mette Marie Babiel Schmidt Petersen, Clara Brinkmann, Julie Birch Petersen, Morten Dunø, Iben Bache, Markus J. Herrgård, Finn Stener Jørgensen, Eva R. Hoffmann, Henriette Svarre Nielsen

引用次数: 0

Abstract

(Abstracted from Lancet 2023;401:762–771 Spontaneous pregnancy loss occurs in approximately 1 in 4 pregnancies; however, diagnostic workup is mostly restricted to women with recurrent pregnancy loss. The lack of workup on first pregnancy loss is likely a result of the high de novo fetal aneuploidy rate; however, this ignores the association of euploid pregnancy loss with an increased risk of future losses.

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哥本哈根妊娠丢失研究(COPL)中无细胞胎儿DNA的遗传评价:一项前瞻性队列研究

(摘自Lancet 2023; 401:762-771)自然流产发生率约为1 / 4;然而，诊断检查主要局限于复发性流产的妇女。缺乏对首次妊娠丢失的检查可能是由于新生儿非整倍体率高;然而，这忽略了整倍体妊娠丢失与未来丢失风险增加的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obstetrical & Gynecological Survey 医学-妇产科学

CiteScore

2.70

自引率

3.20%

发文量

245

审稿时长

>12 weeks

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