Synthesis of alnustone-like diarylpentanoids via a 4 + 1 strategy and assessment of their potential anticancer activity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-31 DOI:10.55730/1300-0527.3609

NESLİHAN ÇELEBİOĞLU, ÖZLEM ÖZDEMİR TOZLU, HASAN TÜRKEZ, HASAN SEÇEN

引用次数: 0

Abstract

Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2- butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.

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4 + 1策略合成阿努斯通样二芳基戊烷类化合物及其潜在抗癌活性评价

合成了12个具有1,5-二芳基-1-戊烯-3- 1结构的化合物，并对其细胞毒活性进行了评价。在吡咯烷- acoh的存在下，通过4-苯基-2-丁酮和4-(4-羟基苯基)-2-丁酮的原位珐琅反应得到1,5-二烷基-1-戊烯-3- 1化合物，然后与6种不同的苯甲醛缩合。合成的化合物对人胶质母细胞瘤(U87-MG)、乳腺(MCF-7)和前列腺(PC-3)癌细胞的细胞毒活性进行了测试。一些新化合物表现出显著的细胞毒性作用，特别是对MCF-7癌细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.