SYNTHESIS OF THREE COMPONENT (GO-CS/ZnO) NANOCOMPOSITE AND FORMULATION OFTHEIR NANO-OINTMENT FOR RAPID WOUND HEALING

Q4 Biochemistry, Genetics and Molecular Biology

Biochemical and Cellular Archives Pub Date : 2023-09-24 DOI:10.51470/bca.2023.23.2.759

Pratima Pandey, Himanshu Pandey, Prashant Kumar Singh Singh, Anil Kumar, Jose Mathew, Avinash C. Pandey

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Abstract

: Implementation of nanotechnology with medicine offers extraordinary openings to synthesize materials at a nanoscale level. The healing of wound is still a demanding area for which an intelligent and efficient treatment is needed. Therefore the present findings have reported the significance of using GO-CS/ZnO based nanoointment on skin wound healing via in vivo investigations. The antibacterial activity of nanocomposite based nanoointment was evaluated by using gram positive Staphylococcus aureus MCCB 0227. The nanocomposites were synthesized and characterized by using X-ray diffraction, SEM, TEM & FTIR. The therapeutic effect of ointments comprising GO–CS/ZnO nanocomposite with different formulations as NO1 (0.1% GO), NO2 (0.1% GO-ZnO), NO3 (0.1% GO-CS) and NO4 (0.1% GO-CS/ZnO) were evaluated in vivo after the creation of wound over the dorsum of mice. As compared to positive control group (treated with marketed formulation gentamicin sulphate 0.1%), NO4 (GO-CS/ZnO) has an efficient antibacterial activity and potential effect on wound dressing and wound care.

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三组分(GO-CS/ZnO)纳米复合材料的合成及其伤口快速愈合纳米软膏的研制

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Biochemical and Cellular Archives Biochemistry, Genetics and Molecular Biology-Biochemistry

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期刊介绍： Biochemical and Cellular Archives – publishes original full length full length research papers, short communications and review articles in all areas of agricultural, biological and medical sciences. Emphasis will be given to manuscript which present novel finding pertinent to the biochemical basis of cellular structure and function as well as mechanism of cellular organelles. Investigations directed towards electron microscopy and localization of biomolecules in cells / tissues are particularly encouraged. The articles for the following broad areas of biological sciences will be considered for publications: ● Cellular Structure, Physiology and Biochemistry. ● Bacteriology, Virology and Toxicology. ● Light and electron microscopy and histochemistry. ● Immunology and molecular biology. ● Pathology.