Research Progress of Estrogen Receptor in Ovarian Cancer

IF 0.4 4区医学 Q4 OBSTETRICS & GYNECOLOGY

Clinical and experimental obstetrics & gynecology Pub Date : 2023-09-24 DOI:10.31083/j.ceog5009199

Mengchen Zhang, Haohui Xu, Yixin Zhang, Zhanfei Li, Wenqiang Meng, Jiayi Xia, Wentao Lei, Kai Meng, Yan Guo

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引用次数: 0

Abstract

Objective: This review aims to provide some theoretical guidance for the precise treatment of ovarian cancer and the development of estrogen-related drugs. Mechanism: Ovarian cancer is one of the leading causes of death in gynecological cancer patients, mainly affecting middle-aged and elderly women. It has the characteristics of hidden location, strong heterogeneity and lack of specific symptoms in the early stage. Numerous studies have shown that estrogen receptor (ER) plays an important role in different types of cancer, including ovarian cancer. Accordingly, the study of ER signaling pathways and related regulatory factors in ovarian cancer cells should help us understand the pathogenesis of ovarian cancer. Findings in Brief: The expression of estrogen receptor subtypes is related to ovarian cancer gene and leads to ovarian cancer. Estrogen receptor modulators appear to be an important factor in the prognosis of patients with ovarian cancer after hormone therapy. Conclusions: This review summarizes the regulatory mechanism of ER in the occurrence and development of ovarian cancer and outlines the specific role of estrogen receptor modulators (SERMs) in the treatment and prevention of ovarian cancer.

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雌激素受体在卵巢癌中的研究进展

目的:为卵巢癌的精准治疗和雌激素相关药物的开发提供理论指导。发病机制:卵巢癌是妇科癌症患者死亡的主要原因之一，主要影响中老年妇女。它具有位置隐匿、异质性强、早期缺乏特异性症状的特点。大量研究表明，雌激素受体(ER)在包括卵巢癌在内的不同类型的癌症中起着重要作用。因此，对卵巢癌细胞内质网信号通路及相关调控因子的研究将有助于我们了解卵巢癌的发病机制。摘要:雌激素受体亚型的表达与卵巢癌基因相关，导致卵巢癌的发生。雌激素受体调节剂似乎是影响卵巢癌患者激素治疗后预后的重要因素。结论:本文综述了雌激素受体在卵巢癌发生发展中的调控机制，概述了雌激素受体调节剂(SERMs)在卵巢癌治疗和预防中的具体作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and experimental obstetrics & gynecology 医学-妇产科学

CiteScore

0.50

自引率

0.00%

发文量

241

审稿时长

1 months

期刊介绍： CEOG is an international, peer-reviewed, open access journal. CEOG covers all aspects of Obstetrics and Gynecology, including obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine. All submissions of cutting-edge advances of medical research in the area of women''s health worldwide are encouraged.