Immunity to mumps virus in children population in Bulgaria

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-13 DOI:10.1080/13102818.2023.2270606

Stefka Krumova, Radostina Stefanova, Savina Stoitsova, Petia Genova-Kalou, Kremena Parmakova

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Abstract

Mumps is an acute, contagious, viral vaccine-preventable disease caused by mumps virus (MuV). The measles, mumps, rubella (MMR) vaccine that is used in many countries is considered highly effective with decreased MuV incidence, but suboptimal MuV long-term immunity. This study assessed the MuV seropositivity and antibody titre among vaccinated children in Bulgaria to provide evidence for a better understanding of MuV circulation and immunity in Bulgaria. The samples from 734 immunized children (369 females and 365 males) aged 1 to 16, divided into four age groups (≥1, 2–6, 7–11, and 12–16) were tested. Qualitative and quantitative indirect enzyme-linked immunosorbent assay (Anti-Mumps IgG ELISA, Euroimmun, Germany) was performed to determine the mumps IgG antibody levels in sera. Among all participants, protective MuV immunity was identified in 93%. MuV IgG antibody positivity ranged between 87% in the age group between 1 and 2 years and 96% in the age group 12–16 years, but no statistically significant difference was found among age groups. At the same time, there was a statistically significant difference (p = 0.01) between seropositivity in male and female participants, with male participants having an overall seropositivity of 90% and female 95%. Among the antibody-positive samples, the quantitative measurements of median anti-MuV IgG concentrations showed that titres decreased with increasing age. A slightly waning immunity following vaccination was observed, but positivity remained high among vaccinated children over the years. Similar studies show that maintaining high immunity is crucial to prevent mumps outbreaks.

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保加利亚儿童对流行性腮腺炎病毒的免疫力

腮腺炎是由腮腺炎病毒(MuV)引起的一种急性、传染性、可通过疫苗预防的病毒性疾病。许多国家使用的麻疹、腮腺炎、风疹(MMR)疫苗被认为是非常有效的，可以降低MuV发病率，但长期免疫力不是最佳的。本研究评估了保加利亚接种疫苗儿童的MuV血清阳性和抗体滴度，为更好地了解保加利亚的MuV循环和免疫提供证据。选取734例1 ~ 16岁儿童(女369例，男365例)，分为≥1岁、2 ~ 6岁、7 ~ 11岁和12 ~ 16岁4个年龄组。采用定性和定量间接酶联免疫吸附法(anti -腮腺炎IgG ELISA, euroimmune，德国)测定血清中腮腺炎IgG抗体水平。在所有参与者中，93%的人具有保护性MuV免疫。1 ~ 2岁年龄组MuV IgG抗体阳性率为87%，12 ~ 16岁年龄组阳性率为96%，但各年龄组间差异无统计学意义。同时，男女受试者血清阳性率差异有统计学意义(p = 0.01)，男性总体血清阳性率为90%，女性总体血清阳性率为95%。在抗体阳性的样本中，抗muv IgG中位浓度的定量测量显示，随着年龄的增长，滴度下降。观察到接种疫苗后免疫力略有下降，但多年来接种疫苗的儿童的阳性率仍然很高。类似的研究表明，保持高免疫力对于预防腮腺炎的爆发至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.