The signal-transduction pathways of the peripheral olfactory organ and their impairment in vertebrates

Q1 Agricultural and Biological Sciences
Arash Shahriari , Bouthaina Aoudi , Keith B. Tierney
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引用次数: 0

Abstract

Animals rely on olfaction to detect and process invaluable chemical information about their environment. For olfaction to function, chemicals must first be detected, which leads to the activation of signal-transduction pathways at the peripheral olfactory organ. As the olfactory system is in direct contact with the environment, the system is constantly vulnerable to damage by contaminants entering the atmosphere or hydrosphere. Contaminants may have a variety of effects, including disrupting olfactory signals generated during chemical detection, or altering numerous targets along the signal transduction pathway. With any impairment of chemical detection, animals may be unable to rely on olfaction to make correct decisions about their environment and thus their fitness. While other reviews have focussed on olfactory toxicology in general, here we specifically explore how contaminants may affect the signal-transduction pathways at various points and link those changes to olfactory functionality across vertebrates with a focus on fishes.

Abstract Image

脊椎动物外周嗅觉器官的信号转导途径及其损伤
动物依靠嗅觉来检测和处理有关其环境的宝贵化学信息。要使嗅觉发挥作用,首先必须检测到化学物质,从而激活外周嗅觉器官的信号转导通路。由于嗅觉系统与环境直接接触,该系统很容易受到进入大气层或水圈的污染物的破坏。污染物可能会产生多种影响,包括干扰化学检测过程中产生的嗅觉信号,或改变信号转导途径上的多个目标。如果化学检测受到任何损害,动物就可能无法依靠嗅觉对环境做出正确的判断,从而影响其生存能力。其他综述侧重于一般的嗅觉毒理学,而在这里,我们特别探讨了污染物可能如何影响信号转导途径的各个环节,并将这些变化与脊椎动物的嗅觉功能联系起来,重点关注鱼类。
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来源期刊
Aquaculture and Fisheries
Aquaculture and Fisheries Agricultural and Biological Sciences-Aquatic Science
CiteScore
7.50
自引率
0.00%
发文量
54
审稿时长
48 days
期刊介绍:
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